Literature DB >> 22948535

New frontiers in the design and synthesis of imaging probes for PET oncology: current challenges and future directions.

Graham Smith1, Laurence Carroll, Eric O Aboagye.   

Abstract

Despite being developed over 30 years ago, 2-deoxy-2-[(18)F]fluoro-D-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.

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Year:  2012        PMID： 22948535     DOI： 10.1007/s11307-012-0590-y

Source DB:  PubMed          Journal:  Mol Imaging Biol        ISSN： 1536-1632            Impact factor:   3.488


  88 in total

Review 1.  Development of radiotracers for oncology--the interface with pharmacology.

Authors:  Rohini Sharma; Eric Aboagye
Journal:  Br J Pharmacol       Date:  2011-08       Impact factor: 8.739

2.  Important parameters to consider for the characterization of PET and SPECT imaging probes.

Authors:  Arvind Chopra; Liang Shan; William C Eckelman; Kam Leung; Anne E Menkens
Journal:  Nucl Med Biol       Date:  2011-08-19       Impact factor: 2.408

3.  PET imaging of hypoxia using [18F]HX4: a phase I trial.

Authors:  Judith van Loon; Marco H M Janssen; Michel Ollers; Hugo J W L Aerts; Ludwig Dubois; Monique Hochstenbag; Anne-Marie C Dingemans; Roy Lalisang; Boudewijn Brans; Bert Windhorst; Guus A van Dongen; Hartmuth Kolb; James Zhang; Dirk De Ruysscher; Philippe Lambin
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-04-06       Impact factor: 9.236

Review 4.  Imaging hypoxia in gliomas.

Authors:  I Mendichovszky; A Jackson
Journal:  Br J Radiol       Date:  2011-12       Impact factor: 3.039

5.  Impact of animal handling on the results of 18F-FDG PET studies in mice.

Authors:  Barbara J Fueger; Johannes Czernin; Isabel Hildebrandt; Chris Tran; Benjamin S Halpern; David Stout; Michael E Phelps; Wolfgang A Weber
Journal:  J Nucl Med       Date:  2006-06       Impact factor: 10.057

6.  5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.

Authors:  Klaus Kopka; Andreas Faust; Petra Keul; Stefan Wagner; Hans-Jörg Breyholz; Carsten Höltke; Otmar Schober; Michael Schäfers; Bodo Levkau
Journal:  J Med Chem       Date:  2006-11-16       Impact factor: 7.446

7.  Synthesis and evaluation of nucleoside radiotracers for imaging proliferation.

Authors:  Graham Smith; Roberta Sala; Laurence Carroll; Kevin Behan; Matthias Glaser; Edward Robins; Quang-Dé Nguyen; Eric O Aboagye
Journal:  Nucl Med Biol       Date:  2012-02-10       Impact factor: 2.408

8.  N(3)-Substituted thymidine analogues V: synthesis and preliminary PET imaging of N(3)-[(18)F]fluoroethyl thymidine and N(3)-[(18)F]fluoropropyl thymidine.

Authors:  Uday Mukhopadhyay; Suren Soghomonyan; Hsin Hsien Yeh; Leo G Flores; Aleksandr Shavrin; Andrei Y Volgin; Juri G Gelovani; Mian M Alauddin
Journal:  Nucl Med Biol       Date:  2008-08       Impact factor: 2.408

9.  Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide.

Authors:  Quang-Dé Nguyen; Graham Smith; Matthias Glaser; Meg Perumal; Erik Arstad; Eric O Aboagye
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-03       Impact factor: 11.205

10.  In vivo VEGF imaging with radiolabeled bevacizumab in a human ovarian tumor xenograft.

Authors:  Wouter B Nagengast; Elisabeth G de Vries; Geke A Hospers; Nanno H Mulder; Johan R de Jong; Harry Hollema; Adrienne H Brouwers; Guus A van Dongen; Lars R Perk; Marjolijn N Lub-de Hooge
Journal:  J Nucl Med       Date:  2007-07-13       Impact factor: 10.057
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  6 in total

Review 1.  Pathogen-Specific Bacterial Imaging in Nuclear Medicine.

Authors:  Alvaro A Ordonez; Sanjay K Jain
Journal:  Semin Nucl Med       Date:  2017-12-14       Impact factor: 4.446

Review 2.  Nuclear imaging: a powerful novel approach for tuberculosis.

Authors:  Daniel H Johnson; Laura E Via; Peter Kim; Dominick Laddy; Chuen-Yen Lau; Edward A Weinstein; Sanjay Jain
Journal:  Nucl Med Biol       Date:  2014-08-07       Impact factor: 2.408

Review 3.  Introduction to the analysis of PET data in oncology.

Authors:  Giampaolo Tomasi; Eric O Aboagye
Journal:  J Pharmacokinet Pharmacodyn       Date:  2013-02-27       Impact factor: 2.745

4.  PET Use in Cancer Diagnosis, Treatment, and Prognosis.

Authors:  Naresh Damuka; Meghana Dodda; Kiran Kumar Solingapuram Sai
Journal:  Methods Mol Biol       Date:  2022

5.  Preliminary biological evaluation of 18F-AlF-NOTA-MAL-Cys-Annexin V as a novel apoptosis imaging agent.

Authors:  Chunxiong Lu; Quanfu Jiang; Minjin Hu; Cheng Tan; Huixin Yu; Zichun Hua
Journal:  Oncotarget       Date:  2017-04-10

6.  Evaluation of apoptosis imaging biomarkers in a genetic model of cell death.

Authors:  Vessela Vassileva; Stephen M Stribbling; Chris Barnes; Laurence Carroll; Marta Braga; Joel Abrahams; Kathrin Heinzmann; Caroline Haegeman; Marion MacFarlane; Kathryn L Simpson; Caroline Dive; Jamie Honeychurch; Timothy M Illidge; Eric O Aboagye
Journal:  EJNMMI Res       Date:  2019-02-19       Impact factor: 3.138
  6 in total

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