Literature DB >> 22947849

Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review.

Yong Pan1, Yuya Nishida, Margaret Wang, Eric Verdin.   

Abstract

The fungicide rapamycin increases lifespan in eukaryotes by interfering with the activity of a serine/threonine kinase called TOR (target of rapamycin). TOR complex 1 (TORC1) is an essential integrator of cellular nutrient cues, growth signals and cellular metabolism. Here, we review major components of TORC1, its downstream effectors and lifespan studies in various organisms involving these signaling components. In particular, we focus on the role of rapamycin in mitochondrial biogenesis, in metabolic regulation and in the control of reactive oxygen species production.
Copyright © 2012 S. Karger AG, Basel.

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Year:  2012        PMID： 22947849     DOI： 10.1159/000342204

Source DB:  PubMed          Journal:  Gerontology        ISSN： 0304-324X            Impact factor:   5.140


  14 in total

1.  Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro.

Authors:  Shasha Guo; Nana Xu; Peng Chen; Ying Liu; Xiaofei Qi; Sheng Liu; Cuixian Li; Jie Tang
Journal:  J Assoc Res Otolaryngol       Date:  2019-06-24

Review 2.  Mitophagy in ischaemia/reperfusion induced cerebral injury.

Authors:  Kangyong Liu; Yinyi Sun; Zhaohua Gu; Nan Shi; Ting Zhang; Xiaojiang Sun
Journal:  Neurochem Res       Date:  2013-04-07       Impact factor: 3.996

3.  Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila.

Authors:  Eugenia Villa-Cuesta; Marissa A Holmbeck; David M Rand
Journal:  J Cell Sci       Date:  2014-03-07       Impact factor: 5.285

4.  Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry.

Authors:  Brian J Morris; Timothy A Donlon; Qimei He; John S Grove; Kamal H Masaki; Ayako Elliott; D Craig Willcox; Richard Allsopp; Bradley J Willcox
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-03-03       Impact factor: 6.053

5.  NMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK).

Authors:  Lisa A M Sommer; Martin Schaad; Sonja A Dames
Journal:  J Biol Chem       Date:  2013-05-13       Impact factor: 5.157

6.  Genetic variation in the raptor gene is associated with overweight but not hypertension in American men of Japanese ancestry.

Authors:  Brian J Morris; Bruce A Carnes; Randi Chen; Timothy A Donlon; Qimei He; John S Grove; Kamal H Masaki; Ayako Elliott; Donald C Willcox; Richard Allsopp; Bradley J Willcox
Journal:  Am J Hypertens       Date:  2014-09-22       Impact factor: 2.689

7.  Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).

Authors:  Michael Ristow; Kathrin Schmeisser
Journal:  Dose Response       Date:  2014-01-31       Impact factor: 2.658

Review 8.  Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases.

Authors:  Danielle L Kirkman; Austin T Robinson; Matthew J Rossman; Douglas R Seals; David G Edwards
Journal:  Am J Physiol Heart Circ Physiol       Date:  2021-04-09       Impact factor: 5.125

9.  Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae.

Authors:  Erine M Stames; John F O'Toole
Journal:  PLoS One       Date:  2013-10-08       Impact factor: 3.240

Review 10.  Mitochondrial aging and age-related dysfunction of mitochondria.

Authors:  Dimitry A Chistiakov; Igor A Sobenin; Victor V Revin; Alexander N Orekhov; Yuri V Bobryshev
Journal:  Biomed Res Int       Date:  2014-04-10       Impact factor: 3.411
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