| Literature DB >> 22946620 |
Kevin K W Kuan1, Henry P Pepper, Witold M Bloch, Jonathan H George.
Abstract
A total synthesis of the marine sponge meroterpenoid (+)-aureol has been achieved in 12 steps (6% overall yield) from (+)-sclareolide. Key steps of the synthesis include a biosynthetically inspired sequence of 1,2-hydride and methyl shifts, and a biomimetic cycloetherification reaction.Entities:
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Year: 2012 PMID： 22946620 DOI： 10.1021/ol301715u
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005