Literature DB >> 22945023

Regio- and stereoselective oxidative phenol coupling in Aspergillus niger.

Christian Gil Girol1, Katja M Fisch, Thorsten Heinekamp, Stefan Günther, Wolfgang Hüttel, Jörn Piel, Axel A Brakhage, Michael Müller.   

Abstract

Piecing it together: Aspergillus niger produces kotanin by dimerization of the monomeric, polyketide-synthase-derived (PKS) 7-demethylsiderin. A combined approach, comprising bioinformatics and gene-deletion experiments, identified the biosynthetic cluster responsible for kotanin production. Homology modeling and substrate docking provide a rationale for the regio- and stereoselective phenol coupling reaction.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22945023     DOI： 10.1002/anie.201203603

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  10 in total

1.  Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization.

Authors:  Scott Griffiths; Carl H Mesarich; Benedetta Saccomanno; Abraham Vaisberg; Pierre J G M De Wit; Russell Cox; Jérôme Collemare
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-06       Impact factor: 11.205

2.  Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica.

Authors:  Jeffrey E Janso; Brad A Haltli; Alessandra S Eustáquio; Kerry Kulowski; Abraham J Waldman; Li Zha; Hitomi Nakamura; Valerie S Bernan; Haiyin He; Guy T Carter; Frank E Koehn; Emily P Balskus
Journal:  Tetrahedron       Date:  2014-07-08       Impact factor: 2.457

Review 3.  Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012-2018).

Authors:  Jillian Romsdahl; Clay C C Wang
Journal:  Medchemcomm       Date:  2019-04-26       Impact factor: 3.597

4.  Transcriptome Analysis of Aspergillus flavus Reveals veA-Dependent Regulation of Secondary Metabolite Gene Clusters, Including the Novel Aflavarin Cluster.

Authors:  J W Cary; Z Han; Y Yin; J M Lohmar; S Shantappa; P Y Harris-Coward; B Mack; K C Ehrlich; Q Wei; N Arroyo-Manzanares; V Uka; L Vanhaecke; D Bhatnagar; J Yu; W C Nierman; M A Johns; D Sorensen; H Shen; S De Saeger; J Diana Di Mavungu; A M Calvo
Journal:  Eukaryot Cell       Date:  2015-07-24

Review 5.  Building Bridges: Biocatalytic C-C-Bond Formation toward Multifunctional Products.

Authors:  Nina G Schmidt; Elisabeth Eger; Wolfgang Kroutil
Journal:  ACS Catal       Date:  2016-06-08       Impact factor: 13.084

Review 6.  Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei.

Authors:  Jens C Frisvad; Lars L H Møller; Thomas O Larsen; Ravi Kumar; José Arnau
Journal:  Appl Microbiol Biotechnol       Date:  2018-10-06       Impact factor: 4.813

7.  Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi.

Authors:  Claudio Greco; Kate de Mattos-Shipley; Andrew M Bailey; Nicholas P Mulholland; Jason L Vincent; Christine L Willis; Russell J Cox; Thomas J Simpson
Journal:  Chem Sci       Date:  2019-01-21       Impact factor: 9.825

8.  Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification.

Authors:  Qingbo Zhang; Huixian Li; Lu Yu; Yu Sun; Yiguang Zhu; Hanning Zhu; Liping Zhang; Shu-Ming Li; Yuemao Shen; Changlin Tian; Ang Li; Hung-Wen Liu; Changsheng Zhang
Journal:  Chem Sci       Date:  2017-05-04       Impact factor: 9.825

9.  Enzymatic Formation of Rufoschweinitzin, a Binaphthalene from the Basidiomycete Cortinarius rufoolivaceus.

Authors:  Wiebke Thiele; Rita Froede; Wolfgang Steglich; Michael Müller
Journal:  Chembiochem       Date:  2020-03-11       Impact factor: 3.164

10.  Antiproliferative and Carbonic Anhydrase II Inhibitory Potential of Chemical Constituents from Lycium shawii and Aloe vera: Evidence from In Silico Target Fishing and In Vitro Testing.

Authors:  Najeeb Ur Rehman; Sobia Ahsan Halim; Majid Khan; Hidayat Hussain; Husain Yar Khan; Ajmal Khan; Ghulam Abbas; Kashif Rafiq; Ahmed Al-Harrasi
Journal:  Pharmaceuticals (Basel)       Date:  2020-05-13
  10 in total

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