| Literature DB >> 22944119 |
Nigel S Simpkins1, Frank Holtrup, Vincent Rodeschini, James D Taylor, Robert Wolf.
Abstract
The synthesis of an unnatural polyprenylated acylphloroglucinol (PPAP), regioisomeric with nemorosone and clusianone, has been accomplished. The separated enantiomers of this new PPAP, along with those of nemorosone and clusianone, have been screened for activity against HeLa (cervix carcinoma), MIA-PaCa-2 (pancreatic carcinoma), and MCF7 (mamma carcinoma) cancer cell lines. All of the isomers examined gave surprisingly similar results in the screens.Entities:
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Year: 2012 PMID： 22944119 DOI： 10.1016/j.bmcl.2012.08.023
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823