Literature DB >> 22941190

Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.

Elizabeth G Holliday1, Jane M Maguire, Tiffany-Jane Evans, Simon A Koblar, Jim Jannes, Jonathan W Sturm, Graeme J Hankey, Ross Baker, Jonathan Golledge, Mark W Parsons, Rainer Malik, Mark McEvoy, Erik Biros, Martin D Lewis, Lisa F Lincz, Roseanne Peel, Christopher Oldmeadow, Wayne Smith, Pablo Moscato, Simona Barlera, Steve Bevan, Joshua C Bis, Eric Boerwinkle, Giorgio B Boncoraglio, Thomas G Brott, Robert D Brown, Yu-Ching Cheng, John W Cole, Ioana Cotlarciuc, William J Devan, Myriam Fornage, Karen L Furie, Sólveig Grétarsdóttir, Andreas Gschwendtner, M Arfan Ikram, W T Longstreth, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Eugenio A Parati, Bruce M Psaty, Pankaj Sharma, Kari Stefansson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Matthew Traylor, Benjamin F J Verhaaren, Kerri L Wiggins, Bradford B Worrall, Cathie Sudlow, Peter M Rothwell, Martin Farrall, Martin Dichgans, Jonathan Rosand, Hugh S Markus, Rodney J Scott, Christopher Levi, John Attia.   

Abstract

Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR)=1.62, P=3.9×10(-8)) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR=1.15, P=3.9×10(-4); discovery and replication combined OR=1.21, P=4.7×10(-8)). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke.

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Year:  2012        PMID： 22941190      PMCID： PMC3651583          DOI： 10.1038/ng.2397

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  35 in total

1.  Practical aspects of imputation-driven meta-analysis of genome-wide association studies.

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2.  Cohort profile: The Hunter Community Study.

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Journal:  Int J Epidemiol       Date:  2010-01-07       Impact factor: 7.196

3.  Estimating missing heritability for disease from genome-wide association studies.

Authors:  Sang Hong Lee; Naomi R Wray; Michael E Goddard; Peter M Visscher
Journal:  Am J Hum Genet       Date:  2011-03-03       Impact factor: 11.025

4.  Common SNPs explain a large proportion of the heritability for human height.

Authors:  Jian Yang; Beben Benyamin; Brian P McEvoy; Scott Gordon; Anjali K Henders; Dale R Nyholt; Pamela A Madden; Andrew C Heath; Nicholas G Martin; Grant W Montgomery; Michael E Goddard; Peter M Visscher
Journal:  Nat Genet       Date:  2010-06-20       Impact factor: 38.330

5.  Heritability of carotid artery atherosclerotic lesions: an ultrasound study in 154 families.

Authors:  Susanna Moskau; Astrid Golla; Christoph Grothe; Monika Boes; Christoph Pohl; Thomas Klockgether
Journal:  Stroke       Date:  2004-11-29       Impact factor: 7.914

6.  Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects.

Authors:  P N Duchateau; I Movsesyan; S Yamashita; N Sakai; K Hirano; S A Schoenhaus; P M O'Connor-Kearns; S J Spencer; R B Jaffe; R F Redberg; B Y Ishida; Y Matsuzawa; J P Kane; M J Malloy
Journal:  J Lipid Res       Date:  2000-08       Impact factor: 5.922

Review 7.  Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke.

Authors:  Enrico Flossmann; Ursula G R Schulz; Peter M Rothwell
Journal:  Stroke       Date:  2003-12-18       Impact factor: 7.914

8.  Heritability of leukoaraiosis in hypertensive sibships.

Authors:  Stephen T Turner; Clifford R Jack; Myriam Fornage; Thomas H Mosley; Eric Boerwinkle; Mariza de Andrade
Journal:  Hypertension       Date:  2004-01-12       Impact factor: 10.190

9.  Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.

Authors:  H P Adams; B H Bendixen; L J Kappelle; J Biller; B B Love; D L Gordon; E E Marsh
Journal:  Stroke       Date:  1993-01       Impact factor: 7.914

10.  Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.

Authors:  Céline Bellenguez; Steve Bevan; Andreas Gschwendtner; Chris C A Spencer; Annette I Burgess; Matti Pirinen; Caroline A Jackson; Matthew Traylor; Amy Strange; Zhan Su; Gavin Band; Paul D Syme; Rainer Malik; Joanna Pera; Bo Norrving; Robin Lemmens; Colin Freeman; Renata Schanz; Tom James; Deborah Poole; Lee Murphy; Helen Segal; Lynelle Cortellini; Yu-Ching Cheng; Daniel Woo; Michael A Nalls; Bertram Müller-Myhsok; Christa Meisinger; Udo Seedorf; Helen Ross-Adams; Steven Boonen; Dorota Wloch-Kopec; Valerie Valant; Julia Slark; Karen Furie; Hossein Delavaran; Cordelia Langford; Panos Deloukas; Sarah Edkins; Sarah Hunt; Emma Gray; Serge Dronov; Leena Peltonen; Solveig Gretarsdottir; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Kari Stefansson; Giorgio B Boncoraglio; Eugenio A Parati; John Attia; Elizabeth Holliday; Chris Levi; Maria-Grazia Franzosi; Anuj Goel; Anna Helgadottir; Jenefer M Blackwell; Elvira Bramon; Matthew A Brown; Juan P Casas; Aiden Corvin; Audrey Duncanson; Janusz Jankowski; Christopher G Mathew; Colin N A Palmer; Robert Plomin; Anna Rautanen; Stephen J Sawcer; Richard C Trembath; Ananth C Viswanathan; Nicholas W Wood; Bradford B Worrall; Steven J Kittner; Braxton D Mitchell; Brett Kissela; James F Meschia; Vincent Thijs; Arne Lindgren; Mary Joan Macleod; Agnieszka Slowik; Matthew Walters; Jonathan Rosand; Pankaj Sharma; Martin Farrall; Cathie L M Sudlow; Peter M Rothwell; Martin Dichgans; Peter Donnelly; Hugh S Markus
Journal:  Nat Genet       Date:  2012-02-05       Impact factor: 38.330
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  90 in total

Review 1.  Genome-wide association studies of late-onset cardiovascular disease.

Authors:  J Gustav Smith; Christopher Newton-Cheh
Journal:  J Mol Cell Cardiol       Date:  2015-04-11       Impact factor: 5.000

2.  Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes.

Authors:  James F Meschia; Donna K Arnett; Hakan Ay; Robert D Brown; Oscar R Benavente; John W Cole; Paul I W de Bakker; Martin Dichgans; Kimberly F Doheny; Myriam Fornage; Raji P Grewal; Katrina Gwinn; Christina Jern; Jordi Jimenez Conde; Julie A Johnson; Katarina Jood; Cathy C Laurie; Jin-Moo Lee; Arne Lindgren; Hugh S Markus; Patrick F McArdle; Leslie A McClure; Braxton D Mitchell; Reinhold Schmidt; Kathryn M Rexrode; Stephen S Rich; Jonathan Rosand; Peter M Rothwell; Tatjana Rundek; Ralph L Sacco; Pankaj Sharma; Alan R Shuldiner; Agnieszka Slowik; Sylvia Wassertheil-Smoller; Cathie Sudlow; Vincent N S Thijs; Daniel Woo; Bradford B Worrall; Ona Wu; Steven J Kittner
Journal:  Stroke       Date:  2013-09-10       Impact factor: 7.914

3.  Common coding variant in SERPINA1 increases the risk for large artery stroke.

Authors:  Rainer Malik; Therese Dau; Maria Gonik; Anirudh Sivakumar; Daniel J Deredge; Evgeniia V Edeleva; Jessica Götzfried; Sander W van der Laan; Gerard Pasterkamp; Nathalie Beaufort; Susana Seixas; Steve Bevan; Lisa F Lincz; Elizabeth G Holliday; Annette I Burgess; Kristiina Rannikmäe; Jens Minnerup; Jennifer Kriebel; Melanie Waldenberger; Martina Müller-Nurasyid; Peter Lichtner; Danish Saleheen; Peter M Rothwell; Christopher Levi; John Attia; Cathie L M Sudlow; Dieter Braun; Hugh S Markus; Patrick L Wintrode; Klaus Berger; Dieter E Jenne; Martin Dichgans
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-06       Impact factor: 11.205

4.  Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.

Authors:  Daniel Woo; Guido J Falcone; William J Devan; W Mark Brown; Alessandro Biffi; Timothy D Howard; Christopher D Anderson; H Bart Brouwers; Valerie Valant; Thomas W K Battey; Farid Radmanesh; Miriam R Raffeld; Sylvia Baedorf-Kassis; Ranjan Deka; Jessica G Woo; Lisa J Martin; Mary Haverbusch; Charles J Moomaw; Guangyun Sun; Joseph P Broderick; Matthew L Flaherty; Sharyl R Martini; Dawn O Kleindorfer; Brett Kissela; Mary E Comeau; Jeremiasz M Jagiella; Helena Schmidt; Paul Freudenberger; Alexander Pichler; Christian Enzinger; Björn M Hansen; Bo Norrving; Jordi Jimenez-Conde; Eva Giralt-Steinhauer; Roberto Elosua; Elisa Cuadrado-Godia; Carolina Soriano; Jaume Roquer; Peter Kraft; Alison M Ayres; Kristin Schwab; Jacob L McCauley; Joanna Pera; Andrzej Urbanik; Natalia S Rost; Joshua N Goldstein; Anand Viswanathan; Eva-Maria Stögerer; David L Tirschwell; Magdy Selim; Devin L Brown; Scott L Silliman; Bradford B Worrall; James F Meschia; Chelsea S Kidwell; Joan Montaner; Israel Fernandez-Cadenas; Pilar Delgado; Rainer Malik; Martin Dichgans; Steven M Greenberg; Peter M Rothwell; Arne Lindgren; Agnieszka Slowik; Reinhold Schmidt; Carl D Langefeld; Jonathan Rosand
Journal:  Am J Hum Genet       Date:  2014-03-20       Impact factor: 11.025

Review 5.  Genetics of ischemic stroke in young adults.

Authors:  Yu-Ching Cheng; John W Cole; Steven J Kittner; Braxton D Mitchell
Journal:  Circ Cardiovasc Genet       Date:  2014-06

Review 6.  Mechanisms and treatment of ischaemic stroke--insights from genetic associations.

Authors:  Hugh S Markus; Steve Bevan
Journal:  Nat Rev Neurol       Date:  2014-10-28       Impact factor: 42.937

7.  Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke.

Authors:  Yuichiro Yamase; Hideki Horibe; Chikara Ueyama; Tetsuo Fujimaki; Mitsutoshi Oguri; Kimihiko Kato; Masazumi Arai; Sachiro Watanabe; Yoshiji Yamada
Journal:  Biomed Rep       Date:  2015-04-29

8.  Association Between TRAF6 Gene Polymorphisms and Susceptibility of Ischemic Stroke in Southern Chinese Han Population.

Authors:  Li Su; Ziwen Chen; Yan Yan; Baoyun Liang; Juanjuan Xie; Qing Chen; Jinjing Tan; Lian Gu
Journal:  J Mol Neurosci       Date:  2015-05-22       Impact factor: 3.444

9.  Fine-Mapping of ABO Gene Identifies Two Novel SNPs Associated with Large Artery Atherosclerotic Stroke in a Chinese Han Population.

Authors:  Hao Zhang; Zhizhong Zhang; Jun Zhang; Lili Xu; Zusen Ye; Yonggang Hao; Biyang Cai; Shuyu Zhou; Keting Liu; Lingli Sun; Wen Sun; Yumeng Zhang; Huan Cai; Guihua Ni; Xinfeng Liu; Gelin Xu
Journal:  Mol Neurobiol       Date:  2016-02-29       Impact factor: 5.590

10.  Association of GWAS-Supported Variants rs556621 on Chromosome 6p21.1 with Large Artery Atherosclerotic Stroke in a Southern Chinese Han Population.

Authors:  Hao Zhang; Qijin Zhai; Zhizhong Zhang; Biyang Cai; Huan Cai; Shuyu Zhou; Lingli Sun; Yi Xie; Deyan Kong; Zongliang Xu; Kunxiong Yuan; Wenjie Zi; Xinfeng Liu; Gelin Xu
Journal:  Neuromolecular Med       Date:  2016-08-27       Impact factor: 3.843
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