Literature DB >> 22940749

The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping.

Steve D M Brown1, Mark W Moore.   

Abstract

Determining the function of all mammalian genes remains a major challenge for the biomedical science community in the 21st century. The goal of the International Mouse Phenotyping Consortium (IMPC) over the next 10 years is to undertake broad-based phenotyping of 20,000 mouse genes, providing an unprecedented insight into mammalian gene function. This short article explores the drivers for large-scale mouse phenotyping and provides an overview of the aims and processes involved in IMPC mouse production and phenotyping.

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Year:  2012        PMID： 22940749      PMCID： PMC3774932          DOI： 10.1007/s00335-012-9427-x

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  18 in total

1.  Introducing the German Mouse Clinic: open access platform for standardized phenotyping.

Authors:  Valérie Gailus-Durner; Helmut Fuchs; Lore Becker; Ines Bolle; Markus Brielmeier; Julia Calzada-Wack; Ralf Elvert; Nicole Ehrhardt; Claudia Dalke; Tobias J Franz; Elisabeth Grundner-Culemann; Stephan Hammelbacher; Sabine M Hölter; Gabriele Hölzlwimmer; Marion Horsch; Anahita Javaheri; S Vetoslav Kalaydjiev; Martina Klempt; Eva Kling; Sandra Kunder; Christoph Lengger; Thomas Lisse; Tomek Mijalski; Beatrix Naton; Vera Pedersen; Cornelia Prehn; Gerhard Przemeck; Ildiko Racz; Claudia Reinhard; Peter Reitmeir; Ilka Schneider; Anja Schrewe; Ralph Steinkamp; Christian Zybill; Jerzy Adamski; Johannes Beckers; Heidrun Behrendt; Jack Favor; Jochen Graw; Gerhard Heldmaier; Heinz Höfler; Boris Ivandic; Hugo Katus; Paulus Kirchhof; Martin Klingenspor; Thomas Klopstock; Andreas Lengeling; Werner Müller; Frauke Ohl; Markus Ollert; Leticia Quintanilla-Martinez; Jörg Schmidt; Holger Schulz; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Dirk H Busch; Martin Hrabé de Angelis
Journal:  Nat Methods       Date:  2005-06       Impact factor: 28.547

2.  Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models.

Authors:  Irina V Larina; Saba H Syed; Narendran Sudheendran; Paul A Overbeek; Mary E Dickinson; Kirill V Larin
Journal:  J Biomed Opt       Date:  2012-08       Impact factor: 3.170

Review 3.  The functional annotation of mammalian genomes: the challenge of phenotyping.

Authors:  Steve D M Brown; Wolfgang Wurst; Ralf Kühn; John M Hancock
Journal:  Annu Rev Genet       Date:  2009       Impact factor: 16.830

4.  Optical projection tomography as a tool for 3D microscopy and gene expression studies.

Authors:  James Sharpe; Ulf Ahlgren; Paul Perry; Bill Hill; Allyson Ross; Jacob Hecksher-Sørensen; Richard Baldock; Duncan Davidson
Journal:  Science       Date:  2002-04-19       Impact factor: 47.728

5.  High-resolution episcopic microscopy: a rapid technique for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology.

Authors:  Wolfgang J Weninger; Stefan H Geyer; Timothy J Mohun; Diego Rasskin-Gutman; Takaaki Matsui; Ines Ribeiro; Luciano da F Costa; Juan Carlos Izpisúa-Belmonte; Gerd B Müller
Journal:  Anat Embryol (Berl)       Date:  2006-01-21

6.  EMPReSS: standardized phenotype screens for functional annotation of the mouse genome.

Authors:  S D M Brown; P Chambon; M Hrabé de Angelis
Journal:  Nat Genet       Date:  2005-11       Impact factor: 38.330

7.  MicroCT for comparative morphology: simple staining methods allow high-contrast 3D imaging of diverse non-mineralized animal tissues.

Authors:  Brian D Metscher
Journal:  BMC Physiol       Date:  2009-06-22

8.  EuroPhenome: a repository for high-throughput mouse phenotyping data.

Authors:  Hugh Morgan; Tim Beck; Andrew Blake; Hilary Gates; Niels Adams; Guillaume Debouzy; Sophie Leblanc; Christoph Lengger; Holger Maier; David Melvin; Hamid Meziane; Dave Richardson; Sara Wells; Jacqui White; Joe Wood; Martin Hrabé de Angelis; Steve D M Brown; John M Hancock; Ann-Marie Mallon
Journal:  Nucleic Acids Res       Date:  2009-11-23       Impact factor: 16.971

9.  Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.

Authors:  Steve D M Brown; John M Hancock; Hilary Gates
Journal:  PLoS Genet       Date:  2006-08-25       Impact factor: 5.917

10.  EuroPhenome and EMPReSS: online mouse phenotyping resource.

Authors:  Ann-Marie Mallon; Andrew Blake; John M Hancock
Journal:  Nucleic Acids Res       Date:  2007-09-28       Impact factor: 16.971
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  154 in total

1.  Scaling up phenotyping studies.

Authors:  Karen L Svenson
Journal:  Nat Biotechnol       Date:  2015-11       Impact factor: 54.908

2.  Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

Authors:  Walter W Chen; Kivanc Birsoy; Maria M Mihaylova; Harriet Snitkin; Iwona Stasinski; Burcu Yucel; Erol C Bayraktar; Jan E Carette; Clary B Clish; Thijn R Brummelkamp; David D Sabatini; David M Sabatini
Journal:  Cell Rep       Date:  2014-03-27       Impact factor: 9.423

3.  Automated pipeline for anatomical phenotyping of mouse embryos using micro-CT.

Authors:  Michael D Wong; Yoshiro Maezawa; Jason P Lerch; R Mark Henkelman
Journal:  Development       Date:  2014-05-21       Impact factor: 6.868

Review 4.  High-throughput mouse phenomics for characterizing mammalian gene function.

Authors:  Steve D M Brown; Chris C Holmes; Ann-Marie Mallon; Terrence F Meehan; Damian Smedley; Sara Wells
Journal:  Nat Rev Genet       Date:  2018-06       Impact factor: 53.242

5.  Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.

Authors:  Daniel M Rotroff; Sook Wah Yee; Kaixin Zhou; Skylar W Marvel; Hetal S Shah; John R Jack; Tammy M Havener; Monique M Hedderson; Michiaki Kubo; Mark A Herman; He Gao; Josyf C Mychaleckyi; Howard L McLeod; Alessandro Doria; Kathleen M Giacomini; Ewan R Pearson; Michael J Wagner; John B Buse; Alison A Motsinger-Reif
Journal:  Diabetes       Date:  2018-04-12       Impact factor: 9.461

Review 6.  Sharing mutations: are biobanks still required in the post-CRISPR/Cas9 era?

Authors:  Janet Kenyon; Martin D Fray
Journal:  Mamm Genome       Date:  2017-07-18       Impact factor: 2.957

7.  Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.

Authors:  Melanie Kahle; Marion Horsch; Barbara Fridrich; Anett Seelig; Jürgen Schultheiß; Jörn Leonhardt; Martin Irmler; Johannes Beckers; Birgit Rathkolb; Eckhard Wolf; Nicole Franke; Valérie Gailus-Durner; Helmut Fuchs; Martin Hrabě de Angelis; Susanne Neschen
Journal:  Mol Metab       Date:  2013-08-03       Impact factor: 7.422

8.  Legal agreements and the governance of research commons: lessons from materials sharing in mouse genomics.

Authors:  Amrita Mishra; Tania Bubela
Journal:  OMICS       Date:  2014-02-19

9.  Long-term experiment to study the development, interaction, and influencing factors of DEXA parameters.

Authors:  Helmut Fuchs; Christine Gau; Wolfgang Hans; Valerie Gailus-Durner; Martin Hrabě de Angelis
Journal:  Mamm Genome       Date:  2013-10-06       Impact factor: 2.957

10.  GigaSOM.jl: High-performance clustering and visualization of huge cytometry datasets.

Authors:  Miroslav Kratochvíl; Oliver Hunewald; Laurent Heirendt; Vasco Verissimo; Jiří Vondrášek; Venkata P Satagopam; Reinhard Schneider; Christophe Trefois; Markus Ollert
Journal:  Gigascience       Date:  2020-11-18       Impact factor: 6.524
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