| Literature DB >> 22940702 |
Nobuyoshi Takeshita1, Mikito Mori, Masayuki Kano, Isamu Hoshino, Yasunori Akutsu, Naoyuki Hanari, Yasuo Yoneyama, Norimasa Ikeda, Yuka Isozaki, Tetsurou Maruyama, Naoki Akanuma, Yukimasa Miyazawa, Hisahiro Matsubara.
Abstract
The expression of microRNA-203 (miR-203) in esophageal squamous cell carcinoma (ESCC) tissues is remarkably lower than that in non‑ESCC tissues. We investigated how miR-203 could influence the development of ESCC cells. Our analyses revealed that miR-203 inhibited the migration and invasion of ESCC cells. Genome-wide gene expression data and target site inhibition assays showed that miR-203 appears to directly regulate LIM and SH3 protein 1 (LASP1). The knockdown of LASP1 resulted in inhibition of the migration and invasion of ESCC cells. Our results suggest that miR-203 and its target LASP1, may be associated with the progression of ESCC. In clinical ESCC specimens, the expression levels of miR-203, which were lower compared to those in normal tissues, were inversely correlated with the mRNA expression levels of LASP1. Moreover, we found that there was a significant correlation between the expression levels of miR-203 and the relapse‑free survival. The identification of a cancer network regulated by miR-203 could provide new insights into the potential mechanisms of the progression of ESCC.Entities:
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Year: 2012 PMID： 22940702 DOI： 10.3892/ijo.2012.1614
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650