Literature DB >> 22940442

miRNA_Targets: a database for miRNA target predictions in coding and non-coding regions of mRNAs.

Amit Kumar1, Adam K-L Wong, Mark L Tizard, Robert J Moore, Christophe Lefèvre.   

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play a role in post-transcriptional regulation of gene expression in most eukaryotes. They help in fine-tuning gene expression by targeting messenger RNAs (mRNA). The interactions of miRNAs and mRNAs are sequence specific and computational tools have been developed to predict miRNA target sites on mRNAs, but miRNA research has been mainly focused on target sites within 3' untranslated regions (UTRs) of genes. There is a need for an easily accessible repository of genome wide full length mRNA - miRNA target predictions with versatile search capabilities and visualization tools. We have created a web accessible database of miRNA target predictions for human, mouse, cow, chicken, Zebra fish, fruit fly and Caenorhabditis elegans using two different target prediction algorithms, The database has target predictions for miRNA's on 5' UTRs, coding region and 3' UTRs of all mRNAs. This database can be freely accessed at http://mamsap.it.deakin.edu.au/mirna_targets/.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID: 22940442     DOI: 10.1016/j.ygeno.2012.08.006

Source DB:  PubMed          Journal:  Genomics        ISSN: 0888-7543            Impact factor:   5.736


  24 in total

Review 1.  miRNAs target databases: developmental methods and target identification techniques with functional annotations.

Authors:  Nagendra Kumar Singh
Journal:  Cell Mol Life Sci       Date:  2017-02-15       Impact factor: 9.261

2.  An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron.

Authors:  Yu Miyazaki; Xiaofei Du; Shin-Ichi Muramatsu; Christopher M Gomez
Journal:  Sci Transl Med       Date:  2016-07-13       Impact factor: 17.956

Review 3.  miRNA - Therapeutic tool in breast cancer? Where are we now?

Authors:  Karolina Zaleska
Journal:  Rep Pract Oncol Radiother       Date:  2014-11-26

4.  MiR-218 inhibits multidrug resistance (MDR) of gastric cancer cells by targeting Hedgehog/smoothened.

Authors:  Xiang-Liang Zhang; Hui-Juan Shi; Ji-Ping Wang; Hong-Sheng Tang; Shu-Zhong Cui
Journal:  Int J Clin Exp Pathol       Date:  2015-06-01

5.  mirDIP 4.1-integrative database of human microRNA target predictions.

Authors:  Tomas Tokar; Chiara Pastrello; Andrea E M Rossos; Mark Abovsky; Anne-Christin Hauschild; Mike Tsay; Richard Lu; Igor Jurisica
Journal:  Nucleic Acids Res       Date:  2018-01-04       Impact factor: 16.971

6.  Determination of the effect of functional single-nucleotide polymorphisms associated with glycerolipid synthesis on intramuscular fat deposition in Korean cattle steer.

Authors:  Hyeongrok Kim; Dong-Yep Oh; Yoonseok Lee
Journal:  Arch Anim Breed       Date:  2021-01-19

Review 7.  Recent insights and novel bioinformatics tools to understand the role of microRNAs binding to 5' untranslated region.

Authors:  Letizia Da Sacco; Andrea Masotti
Journal:  Int J Mol Sci       Date:  2012-12-27       Impact factor: 5.923

Review 8.  Nematode endogenous small RNA pathways.

Authors:  Suzanne W Hoogstrate; Rita Jm Volkers; Mark G Sterken; Jan E Kammenga; L Basten Snoek
Journal:  Worm       Date:  2014-03-05

9.  Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii).

Authors:  Vengamanaidu Modepalli; Amit Kumar; Lyn A Hinds; Julie A Sharp; Kevin R Nicholas; Christophe Lefevre
Journal:  BMC Genomics       Date:  2014-11-23       Impact factor: 3.969

10.  Characterization of miR-206 Promoter and Its Association with Birthweight in Chicken.

Authors:  Xinzheng Jia; Huiran Lin; Bahareldin Ali Abdalla; Qinghua Nie
Journal:  Int J Mol Sci       Date:  2016-04-14       Impact factor: 5.923

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