Literature DB >> 2294015

Phosphatidylinositol hydrolysis by human plasma phospholipase D.

J Balsinde1, F Mollinedo.   

Abstract

A phospholipase D activity able to hydrolyze phosphatidylinositol has previously been described in the cytosol of human neutrophils. The experiments reported here demonstrate that this phosphatidylinositol-hydrolyzing phospholipase D activity is also present in human plasma. This activity was assessed by free inositol release from phosphatidylinositol substrate, by phosphatidate formation and by phosphatidylethanol formation through its capacity of catalyzing a transphosphatidylation reaction. This plasma enzyme activity shows an optimum pH of 8.0 and is inhibited by EGTA.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2294015     DOI： 10.1016/0014-5793(90)80017-d

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  Phospholipase D-modified low density lipoprotein is taken up by macrophages at increased rate. A possible role for phosphatidic acid.

Authors:  M Aviram; I Maor
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

2.  v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters.

Authors:  J Song; D A Foster
Journal:  Biochem J       Date:  1993-09-15       Impact factor: 3.857

3.  Phospholipase D activation in human natural killer cells through the Kp43 and CD16 surface antigens takes place by different mechanisms. Involvement of the phospholipase D pathway in tumor necrosis factor alpha synthesis.

Authors:  M A Balboa; J Balsinde; J Aramburu; F Mollinedo; M López-Botet
Journal:  J Exp Med       Date:  1992-07-01       Impact factor: 14.307
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.