Literature DB >> 22939572

Identification, characterization and suppression of side-products formed during the synthesis of high dose ⁶⁸Ga-DOTA-TATE.

Linjing Mu1, Rolf Hesselmann, Ufuk Oezdemir, Louis Bertschi, Alain Blanc, Martina Dragic, Dirk Löffler, Christoph Smuda, Anass Johayem, Roger Schibli.   

Abstract

In the course of the establishment of (68)Ga-DOTA-TATE production for clinical use a shoulder comprising presumably several impurities was observed in the chromatogram of the analytical radio-HPLC. LC-MS/MS results support the hypothesis that some of these radioimpurities are radiolytic oxidation by-products of (68)Ga-DOTA-TATE. A new HPLC method was developed for quality control of (68)Ga-DOTA-TATE. Significant improvement on the radiochemical purity of (68)Ga-DOTA-TATE was achieved by the addition of ascorbic acid or ethanol to the reaction mixture.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22939572     DOI： 10.1016/j.apradiso.2012.07.022

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  10 in total

1.  Preclinical Investigation of 212Pb-DOTAMTATE for Peptide Receptor Radionuclide Therapy in a Neuroendocrine Tumor Model.

Authors:  Tania A Rozgaja Stallons; Amal Saidi; Izabela Tworowska; Ebrahim S Delpassand; Julien J Torgue
Journal:  Mol Cancer Ther       Date:  2019-03-29       Impact factor: 6.261

Review 2.  Good practices for 68Ga radiopharmaceutical production.

Authors:  Bryce J B Nelson; Jan D Andersson; Frank Wuest; Sarah Spreckelmeyer
Journal:  EJNMMI Radiopharm Chem       Date:  2022-10-22

3.  Development of single vial kits for preparation of (68)Ga-labelled peptides for PET imaging of neuroendocrine tumours.

Authors:  Archana Mukherjee; Usha Pandey; Rubel Chakravarty; Haladhar Dev Sarma; Ashutosh Dash
Journal:  Mol Imaging Biol       Date:  2014-08       Impact factor: 3.488

4.  Radiosynthesis of clinical doses of ⁶⁸Ga-DOTATATE (GalioMedix™) and validation of organic-matrix-based ⁶⁸Ge/⁶⁸Ga generators.

Authors:  Izabela Tworowska; David Ranganathan; Sanjay Thamake; Ebrahim Delpassand; Alireza Mojtahedi; Michael K Schultz; Konstantin Zhernosekov; Sebastian Marx
Journal:  Nucl Med Biol       Date:  2015-09-01       Impact factor: 2.408

5.  Novel Preclinical and Radiopharmaceutical Aspects of [68Ga]Ga-PSMA-HBED-CC: A New PET Tracer for Imaging of Prostate Cancer.

Authors:  Matthias Eder; Oliver Neels; Miriam Müller; Ulrike Bauder-Wüst; Yvonne Remde; Martin Schäfer; Ute Hennrich; Michael Eisenhut; Ali Afshar-Oromieh; Uwe Haberkorn; Klaus Kopka
Journal:  Pharmaceuticals (Basel)       Date:  2014-06-30

6.  Automated synthesis of [68Ga]Ga-FAPI-46 without pre-purification of the generator eluate on three common synthesis modules and two generator types.

Authors:  Ammar Alfteimi; Ulf Lützen; Alexander Helm; Michael Jüptner; Marlies Marx; Yi Zhao; Maaz Zuhayra
Journal:  EJNMMI Radiopharm Chem       Date:  2022-07-29

7.  68Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers.

Authors:  Henri Baudhuin; Julie Cousaert; Philippe Vanwolleghem; Geert Raes; Vicky Caveliers; Marleen Keyaerts; Tony Lahoutte; Catarina Xavier
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-10

8.  Characterization of SnO2-based (68)Ge/ (68)Ga generators and (68)Ga-DOTATATE preparations: radionuclide purity, radiochemical yield and long-term constancy.

Authors:  Ferdinand Sudbrock; Thomas Fischer; Beate Zimmermanns; Mehrab Guliyev; Markus Dietlein; Alexander Drzezga; Klaus Schomäcker
Journal:  EJNMMI Res       Date:  2014-07-24       Impact factor: 3.138

9.  Ethanol effects on 68Ga-radiolabelling efficacy and radiolysis in automated synthesis utilizing NaCl post-processing.

Authors:  Michael Meisenheimer; Stefan Kürpig; Markus Essler; Elisabeth Eppard
Journal:  EJNMMI Radiopharm Chem       Date:  2019-10-07

10.  Development and Validation of an Analytical HPLC Method to Assess Chemical and Radiochemical Purity of [68Ga]Ga-NODAGA-Exendin-4 Produced by a Fully Automated Method.

Authors:  Silvia Migliari; Antonino Sammartano; Marti Boss; Martin Gotthardt; Maura Scarlattei; Giorgio Baldari; Claudia Silva; Riccardo C Bonadonna; Livia Ruffini
Journal:  Molecules       Date:  2022-01-15       Impact factor: 4.411
  10 in total

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