Literature DB >> 22938967

Maturation of the human brain and epilepsy.

Gregory L Holmes1, M D Mathieu Milh, Olivier Dulac.   

Abstract

All features of childhood epilepsy are intimately related to brain development. The clinical EEG features of seizures are closely related to developmental changes in cell growth, synapse formation, and myelination. The immature brain is highly excitable due to the depolarizing effects of GABA, overexpression of glutamatergic receptors, and lack of efficient inhibitory control. Seizures have an age-specific effect on brain development.Whereas early life seizures rarely result in cell loss, they can induce changes in synapse organization and receptor physiology.

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Year:  2012        PMID： 22938967     DOI： 10.1016/B978-0-444-52898-8.00007-0

Source DB:  PubMed          Journal:  Handb Clin Neurol        ISSN： 0072-9752


  7 in total

1.  Autism and Epilepsy: Exploring the Relationship Using Experimental Models.

Authors:  Carl E Stafstrom; Tim A Benke
Journal:  Epilepsy Curr       Date:  2015 Jul-Aug       Impact factor: 7.500

2.  Gray Matter Age Prediction as a Biomarker for Risk of Dementia.

Authors:  Johnny Wang; Maria J Knol; Aleksei Tiulpin; Florian Dubost; Marleen de Bruijne; Meike W Vernooij; Hieab H H Adams; M Arfan Ikram; Wiro J Niessen; Gennady V Roshchupkin
Journal:  Proc Natl Acad Sci U S A       Date:  2019-10-01       Impact factor: 11.205

3.  Homozygous variant p.(Arg163Trp) in PIGH causes glycosylphosphatidylinositol biosynthesis defect with epileptic encephalopathy and delayed myelination.

Authors:  Michelle C do Rosario; Parneet Kaur; Katta Mohan Girisha; Stephanie Bielas; Anju Shukla
Journal:  Clin Dysmorphol       Date:  2022-04-19       Impact factor: 0.884

4.  Epigenetic Suppression of GADs Expression is Involved in Temporal Lobe Epilepsy and Pilocarpine-Induced Mice Epilepsy.

Authors:  Jin-Gang Wang; Qing Cai; Jun Zheng; Yu-Shu Dong; Jin-Jiang Li; Jing-Chen Li; Guang-Zhi Hao; Chao Wang; Ju-Lei Wang
Journal:  Neurochem Res       Date:  2016-05-25       Impact factor: 3.996

5.  White matter brain aging in relationship to schizophrenia and its cognitive deficit.

Authors:  Jingtao Wang; Peter Kochunov; Hemalatha Sampath; Kathryn S Hatch; Meghann C Ryan; Fuzhong Xue; Jahanshad Neda; Thompson Paul; Britta Hahn; James Gold; James Waltz; L Elliot Hong; Shuo Chen
Journal:  Schizophr Res       Date:  2021-03-02       Impact factor: 4.939

6.  Development and validation of a nomogram for the early prediction of drug resistance in children with epilepsy.

Authors:  Hua Geng; Xuqin Chen
Journal:  Front Pediatr       Date:  2022-08-30       Impact factor: 3.569

Review 7.  Neonatal Seizures: Impact on Neurodevelopmental Outcomes.

Authors:  Seok Kyu Kang; Shilpa D Kadam
Journal:  Front Pediatr       Date:  2015-11-23       Impact factor: 3.418
  7 in total

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