Literature DB >> 22937974

Synthetic study of pyrrocidines: first entry to the decahydrofluorene core of pyrrocidines.

Ryo Tanaka1, Kentaro Ohishi, Noriyuki Takanashi, Tomohiko Nagano, Hiroshi Suizu, Takahiro Suzuki, Susumu Kobayashi.   

Abstract

The first synthesis of decahydrofluorene core 4 of pyrrocidines was accomplished. The cis,trans-fused tricyclic ring system was stereoselectively constructed via Diels-Alder reaction using two Danishefsky dienes.

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Year:  2012        PMID： 22937974     DOI： 10.1021/ol3022116

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition.

Authors:  Shota Uesugi; Nozomi Fujisawa; Jun Yoshida; Mitsuru Watanabe; Shingo Dan; Takao Yamori; Yoshihito Shiono; Ken-ichi Kimura
Journal:  J Antibiot (Tokyo)       Date:  2015-10-28       Impact factor: 2.649

2.  Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products.

Authors:  Masao Ohashi; Thomas B Kakule; Man-Cheng Tang; Cooper S Jamieson; Mengting Liu; Yi-Lei Zhao; Kendall N Houk; Yi Tang
Journal:  J Am Chem Soc       Date:  2021-04-09       Impact factor: 15.419

3.  Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with XenF-mediated sigmatropic rearrangement as a prerequisite.

Authors:  Zhiguo Liu; Wei Li; Peng Zhang; Jie Fan; Fangbo Zhang; Caixia Wang; Shuming Li; Yi Sun; Shilin Chen; Wenbing Yin
Journal:  Acta Pharm Sin B       Date:  2021-03-26       Impact factor: 11.413
  3 in total

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