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Literature DB >> 22937212

Krüppel-like factor 8 emerges as an important regulator of cancer.

Abstract

Krüppel-like factor 8 (KLF8) is a young member of the KLF transcription factor family proteins. It is highly overexpressed in several types of human cancers and regulates various cellular processes important for tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.

Entities: Disease Gene Species

Keywords: Keywords: Krüppel-like factor 8 (KLF8); cancer

Year: 2012 PMID： 22937212 PMCID： PMC3426389

Source DB: PubMed Journal: Am J Transl Res Impact factor: 4.060

31 in total

Review 1. Krüppel-like factors: three fingers in many pies.

Authors: J J Bieker
Journal: J Biol Chem Date: 2001-07-06 Impact factor: 5.157

2. Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.

Authors: Xianhui Wang; Mingzhe Zheng; Gang Liu; Weiya Xia; Paula J McKeown-Longo; Mien-Chie Hung; Jihe Zhao
Journal: Cancer Res Date: 2007-08-01 Impact factor: 12.701

Review 3. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation.

Authors: Braden D Cox; Meera Natarajan; Michelle R Stettner; Candece L Gladson
Journal: J Cell Biochem Date: 2006-09-01 Impact factor: 4.429

4. Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription.

Authors: J van Vliet; J Turner; M Crossley
Journal: Nucleic Acids Res Date: 2000-05-01 Impact factor: 16.971

5. p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain.

Authors: Qiang Ding; J Robert Grammer; Mark A Nelson; Jun-Lin Guan; Jerry E Stewart; Candece L Gladson
Journal: J Biol Chem Date: 2004-11-19 Impact factor: 5.157

6. Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation.

Authors: A M Lossi; F Laugier-Anfossi; D Depetris; J Gecz; A Gedeon; F Kooy; C Schwartz; M G Mattei; M F Croquette; L Villard
Journal: J Med Genet Date: 2002-02 Impact factor: 6.318

7. Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells.

Authors: Xianhui Wang; Alison M Urvalek; Jinsong Liu; Jihe Zhao
Journal: J Biol Chem Date: 2008-03-19 Impact factor: 5.157

8. Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer.

Authors: Weidong Zhao; Irfan M Hisamuddin; Mandayam O Nandan; Brian A Babbin; Neil E Lamb; Vincent W Yang
Journal: Oncogene Date: 2004-01-15 Impact factor: 9.867

9. Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.

Authors: Jihe Zhao; Z Christine Bian; Kristine Yee; Benjamin P C Chen; Shu Chien; Jun-Lin Guan
Journal: Mol Cell Date: 2003-06 Impact factor: 17.970

Review 10. Signal transduction by focal adhesion kinase in cancer.

Authors: Jihe Zhao; Jun-Lin Guan
Journal: Cancer Metastasis Rev Date: 2009-06 Impact factor: 9.264

25 in total

Review 1. Krüppel-like factors in cancer.

Authors: Marie-Pier Tetreault; Yizeng Yang; Jonathan P Katz
Journal: Nat Rev Cancer Date: 2013-10 Impact factor: 60.716

Review 2. Regulatory networks defining EMT during cancer initiation and progression.

Authors: Bram De Craene; Geert Berx
Journal: Nat Rev Cancer Date: 2013-02 Impact factor: 60.716

3. Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR.

Authors: Suman Govindaraju; Beth S Lee
Journal: Cell Physiol Biochem Date: 2014-08-08

4. Krüppel-like factor 8 induces epithelial-to-mesenchymal transition and promotes invasion of pancreatic cancer cells through transcriptional activation of four and a half LIM-only protein 2.

Authors: Xiaoping Yi; Hongyan Zai; Xueying Long; Xiaoyi Wang; Wenzheng Li; Yixiong Li
Journal: Oncol Lett Date: 2017-08-09 Impact factor: 2.967

5. Krüppel-like factor 5 as potential molecular marker in cervical cancer and the KLF family profile expression.

Authors: Daniel Marrero-Rodríguez; Keiko Taniguchi-Ponciano; Florinda Jimenez-Vega; Pablo Romero-Morelos; Monica Mendoza-Rodríguez; Alejandra Mantilla; Miriam Rodriguez-Esquivel; Daniel Hernandez; Angeles Hernandez; Guillermo Gomez-Gutierrez; Nancy Muñoz-Hernandez; Hugo Arreola-de la Cruz; Claudia Vargas-Requena; Cecilia Díaz-Hernández; Luis Serna-Reyna; Marco Meraz-Rios; Cindy Bandala; Jorge Ortiz-Leon; Mauricio Salcedo
Journal: Tumour Biol Date: 2014-08-15

Review 6. Krüppel-like factors in mammalian stem cells and development.

Authors: Agnieszka B Bialkowska; Vincent W Yang; Sandeep K Mallipattu
Journal: Development Date: 2017-03-01 Impact factor: 6.868

7. Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing.

Authors: Alister P W Funnell; Ka Sin Mak; Natalie A Twine; Gregory J Pelka; Laura J Norton; Tania Radziewic; Melinda Power; Marc R Wilkins; Kim S Bell-Anderson; Stuart T Fraser; Andrew C Perkins; Patrick P Tam; Richard C M Pearson; Merlin Crossley
Journal: Mol Cell Biol Date: 2013-05-28 Impact factor: 4.272