Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides.

Literature DB >> 22936396

Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides.

Yunyan Kuang¹, Huabing Sun, J Craig Blain, Xiaohua Peng.

Abstract

The clean crossed code: Two nitroimidazole-modified thymidines 1 a and 1 b were synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1 a and 1 b generated a 5-(2'-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL; see scheme). A higher ICL yield was observed under hypoxic conditions than under aerobic conditions.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22936396 PMCID： PMC3525362 DOI： 10.1002/chem.201201960

Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236

24 in total

Review 1. Formation and repair of interstrand cross-links in DNA.

Authors: David M Noll; Tracey McGregor Mason; Paul S Miller
Journal: Chem Rev Date: 2006-02 Impact factor: 60.622

2. Radiosensitization by a modified nucleotide that produces DNA interstrand cross-links under hypoxic conditions.

Authors: In Seok Hong; Hui Ding; Marc M Greenberg
Journal: J Am Chem Soc Date: 2006-02-22 Impact factor: 15.419

3. DNA interstrand cross-link formation initiated by reaction between singlet oxygen and a modified nucleotide.

Authors: In Seok Hong; Marc M Greenberg
Journal: J Am Chem Soc Date: 2005-08-03 Impact factor: 15.419

4. Efficient DNA interstrand cross-link formation from a nucleotide radical.

Authors: In Seok Hong; Marc M Greenberg
Journal: J Am Chem Soc Date: 2005-03-23 Impact factor: 15.419

5. The reactivity of the 5-hydroxy-5,6-dihydrothymidin-6-yl radical in oligodeoxyribonucleotides.

Authors: Qibin Zhang; Yinsheng Wang
Journal: Chem Res Toxicol Date: 2005-12 Impact factor: 3.739

6. Mild generation of 5-(2'-deoxyuridinyl)methyl radical from a phenyl selenide precursor.

Authors: In Seok Hong; Marc M Greenberg
Journal: Org Lett Date: 2004-12-23 Impact factor: 6.005

7. Oxygen independent DNA interstrand cross-link formation by a nucleotide radical.

Authors: In Seok Hong; Hui Ding; Marc M Greenberg
Journal: J Am Chem Soc Date: 2006-01-18 Impact factor: 15.419

8. Interstrand cross-links: a new type of gamma-ray damage in bromodeoxyuridine-substituted DNA.

Authors: Sylvain Cecchini; Sonia Girouard; Michael A Huels; Léon Sanche; Darel J Hunting
Journal: Biochemistry Date: 2005-02-15 Impact factor: 3.162

Review 9. Radiation-activated prodrugs as hypoxia-selective cytotoxins: model studies with nitroarylmethyl quaternary salts.

Authors: W R Wilson; M Tercel; R F Anderson; W A Denny
Journal: Anticancer Drug Des Date: 1998-09

10. The histological structure of some human lung cancers and the possible implications for radiotherapy.

Authors: R H THOMLINSON; L H GRAY
Journal: Br J Cancer Date: 1955-12 Impact factor: 7.640

6 in total

1. Photoswitchable formation of a DNA interstrand cross-link by a coumarin-modified nucleotide.

Authors: Mohammad Mojibul Haque; Huabing Sun; Shuo Liu; Yinsheng Wang; Xiaohua Peng
Journal: Angew Chem Int Ed Engl Date: 2014-05-19 Impact factor: 15.336

2. Deconvoluting the reactivity of two intermediates formed from modified pyrimidines.

Authors: Liwei Weng; Sonia M Horvat; Carl H Schiesser; Marc M Greenberg
Journal: Org Lett Date: 2013-07-03 Impact factor: 6.005

3. Spatial and Temporal Resolution of the Oxygen-Independent Photoinduced DNA Interstrand Cross-Linking by a Nitroimidazole Derivative.

Authors: Abdelazim M A Abdelgawwad; Antonio Monari; Iñaki Tuñón; Antonio Francés-Monerris
Journal: J Chem Inf Model Date: 2022-06-30 Impact factor: 6.162