Literature DB >> 22936337

Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX.

Brett Waybrant1, Timothy R Pearce, Ping Wang, Srinand Sreevatsan, Efrosini Kokkoli.   

Abstract

Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.

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Year:  2012        PMID： 22936337     DOI： 10.1039/c2cc34217k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  The impact of immobilized metal affinity chromatography (IMAC) resins on DNA aptamer selection.

Authors:  E Kowalska; F Bartnicki; K Pels; W Strzalka
Journal:  Anal Bioanal Chem       Date:  2014-06-13       Impact factor: 4.142

2.  Analysis and Identification of Aptamer-Compound Interactions with a Maximum Relevance Minimum Redundancy and Nearest Neighbor Algorithm.

Authors:  ShaoPeng Wang; Yu-Hang Zhang; Jing Lu; Weiren Cui; Jerry Hu; Yu-Dong Cai
Journal:  Biomed Res Int       Date:  2016-02-03       Impact factor: 3.411

3.  Oligonucleotide aptamers: new tools for targeted cancer therapy.

Authors:  Hongguang Sun; Xun Zhu; Patrick Y Lu; Roberto R Rosato; Wen Tan; Youli Zu
Journal:  Mol Ther Nucleic Acids       Date:  2014-08-05       Impact factor: 10.183
  3 in total

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