Yisi Wang1, Liqun Zou, Ming Jiang, Yuquan Wei, Yu Jiang. 1. Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Abstract
PURPOSE: The aim of this study was to assess the levels and sources of distress in patients with lymphoma. This study also focused on the influence of factors of the level of distress and the cutoff score using the Distress Thermometer (DT) relative to the Hospital Anxiety and Depression Scale (HADS). METHOD: DT and HADS were used to estimate the psychological status of 323 eligible lymphoma patients. The DT was evaluated against the HADS for its sensitivity and specificity. RESULTS: One hundred and ninety-three (59.7%) lymphoma patients experienced overall distress on the HADS, with 137 (42.4%) experiencing anxiety and 114 (35.3%) suffering from depression. There were 199 (61.6%) and 163 (50.5%) patients with distress score ≥ 4 and ≥ 5, respectively. DT was significantly correlated with the HADS-total (T) (r=0.820, p<0.001), HADS-depression (D) (r=0.763, p<0.001), and HADS-anxiety (A) (r=0.738, p<0.001). The consistency of the DT and HADS was favorable (coherence index=0.6030, p<0.01) when the cutoff score was 5 for the DT. Referring to the cutoff of 15 on HADS, 5 on DT yielded optimal specificity (0.869, p<0.001) and sensitivity (0.756, p<0.001). In multiple logistic regression analysis, patients with 'B symptoms' were more likely to have a distress score ≥ 5 [OR=4.512, p<0.05, 95% CI 1.953-10.467]. CONCLUSION: DT is efficacious for screening for anxiety and depression in lymphoma patients.
PURPOSE: The aim of this study was to assess the levels and sources of distress in patients with lymphoma. This study also focused on the influence of factors of the level of distress and the cutoff score using the Distress Thermometer (DT) relative to the Hospital Anxiety and Depression Scale (HADS). METHOD:DT and HADS were used to estimate the psychological status of 323 eligible lymphomapatients. The DT was evaluated against the HADS for its sensitivity and specificity. RESULTS: One hundred and ninety-three (59.7%) lymphomapatients experienced overall distress on the HADS, with 137 (42.4%) experiencing anxiety and 114 (35.3%) suffering from depression. There were 199 (61.6%) and 163 (50.5%) patients with distress score ≥ 4 and ≥ 5, respectively. DT was significantly correlated with the HADS-total (T) (r=0.820, p<0.001), HADS-depression (D) (r=0.763, p<0.001), and HADS-anxiety (A) (r=0.738, p<0.001). The consistency of the DT and HADS was favorable (coherence index=0.6030, p<0.01) when the cutoff score was 5 for the DT. Referring to the cutoff of 15 on HADS, 5 on DT yielded optimal specificity (0.869, p<0.001) and sensitivity (0.756, p<0.001). In multiple logistic regression analysis, patients with 'B symptoms' were more likely to have a distress score ≥ 5 [OR=4.512, p<0.05, 95% CI 1.953-10.467]. CONCLUSION:DT is efficacious for screening for anxiety and depression in lymphomapatients.
Authors: Xuelei Ma; Jing Zhang; Wuning Zhong; Chi Shu; Fengtian Wang; Jianing Wen; Min Zhou; Yaxiong Sang; Yu Jiang; Lei Liu Journal: Support Care Cancer Date: 2014-02-08 Impact factor: 3.603
Authors: Michelle B Riba; Kristine A Donovan; Barbara Andersen; IIana Braun; William S Breitbart; Benjamin W Brewer; Luke O Buchmann; Matthew M Clark; Molly Collins; Cheyenne Corbett; Stewart Fleishman; Sofia Garcia; Donna B Greenberg; Rev George F Handzo; Laura Hoofring; Chao-Hui Huang; Robin Lally; Sara Martin; Lisa McGuffey; William Mitchell; Laura J Morrison; Megan Pailler; Oxana Palesh; Francine Parnes; Janice P Pazar; Laurel Ralston; Jaroslava Salman; Moreen M Shannon-Dudley; Alan D Valentine; Nicole R McMillian; Susan D Darlow Journal: J Natl Compr Canc Netw Date: 2019-10-01 Impact factor: 11.908
Authors: Andreas Kiesbye Øvlisen; Lasse Hjort Jakobsen; Kristian Hay Kragholm; René Ernst Nielsen; Peter de Nully Brown; Rasmus Bo Dahl-Sørensen; Henrik Frederiksen; Nikolaj Mannering; Pär Lars Josefsson; Ahmed Ludvigsen Al-Mashhadi; Judit Mészáros Jørgensen; Andriette Dessau-Arp; Michael Roost Clausen; Robert Schou Pedersen; Christian Torp-Pedersen; Marianne Tang Severinsen; Tarec Christoffer El-Galaly Journal: Am J Hematol Date: 2022-03-29 Impact factor: 13.265