Literature DB >> 22935789

Down's syndrome and Alzheimer's disease: towards secondary prevention.

Seth Ness1, Michael Rafii, Paul Aisen, Michael Krams, Wayne Silverman, Husseini Manji.   

Abstract

A public-private partnership to establish biomarkers of dementia in Down's syndrome could aid the development of preventive therapies for the dementia associated with both Down's syndrome and Alzheimer's disease, based on the apparent common pathogenic role of amyloid precursor protein in the two conditions.

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Year:  2012        PMID： 22935789     DOI： 10.1038/nrd3822

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  4 in total

Review 1.  Alzheimer's disease in Down syndrome: neurobiology and risk.

Authors:  Warren B Zigman; Ira T Lott
Journal:  Ment Retard Dev Disabil Res Rev       Date:  2007

2.  I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy.

Authors:  A D Barker; C C Sigman; G J Kelloff; N M Hylton; D A Berry; L J Esserman
Journal:  Clin Pharmacol Ther       Date:  2009-05-13       Impact factor: 6.875

3.  A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

Authors:  Thorlakur Jonsson; Jasvinder K Atwal; Stacy Steinberg; Jon Snaedal; Palmi V Jonsson; Sigurbjorn Bjornsson; Hreinn Stefansson; Patrick Sulem; Daniel Gudbjartsson; Janice Maloney; Kwame Hoyte; Amy Gustafson; Yichin Liu; Yanmei Lu; Tushar Bhangale; Robert R Graham; Johanna Huttenlocher; Gyda Bjornsdottir; Ole A Andreassen; Erik G Jönsson; Aarno Palotie; Timothy W Behrens; Olafur T Magnusson; Augustine Kong; Unnur Thorsteinsdottir; Ryan J Watts; Kari Stefansson
Journal:  Nature       Date:  2012-08-02       Impact factor: 49.962

4.  A human stem cell model of early Alzheimer's disease pathology in Down syndrome.

Authors:  Yichen Shi; Peter Kirwan; James Smith; Glenn MacLean; Stuart H Orkin; Frederick J Livesey
Journal:  Sci Transl Med       Date:  2012-02-15       Impact factor: 17.956
  4 in total
  22 in total

1.  Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease.

Authors:  Paul S Aisen; Bruno Vellas; Harald Hampel
Journal:  Nat Rev Drug Discov       Date:  2013-03-15       Impact factor: 84.694

2.  The AT(N) framework for Alzheimer's disease in adults with Down syndrome.

Authors:  Michael S Rafii; Beau M Ances; Nicole Schupf; Sharon J Krinsky-McHale; Mark Mapstone; Wayne Silverman; Ira Lott; William Klunk; Elizabeth Head; Brad Christian; Florence Lai; H Diana Rosas; Shahid Zaman; Melissa E Petersen; Andre Strydom; Juan Fortea; Benjamin Handen; Sid O'Bryant
Journal:  Alzheimers Dement (Amst)       Date:  2020-10-27

3.  Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society.

Authors:  Jean-Maurice Delabar; Bernadette Allinquant; Diana Bianchi; Tom Blumenthal; Alain Dekker; Jamie Edgin; John O'Bryan; Mara Dierssen; Marie-Claude Potier; Frances Wiseman; Faycal Guedj; Nicole Créau; Roger Reeves; Katheleen Gardiner; Jorge Busciglio
Journal:  Mol Syndromol       Date:  2016-09-16

Review 4.  Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014.

Authors:  Michael W Weiner; Dallas P Veitch; Paul S Aisen; Laurel A Beckett; Nigel J Cairns; Jesse Cedarbaum; Michael C Donohue; Robert C Green; Danielle Harvey; Clifford R Jack; William Jagust; John C Morris; Ronald C Petersen; Andrew J Saykin; Leslie Shaw; Paul M Thompson; Arthur W Toga; John Q Trojanowski
Journal:  Alzheimers Dement       Date:  2015-07       Impact factor: 21.566

5.  Down syndrome and Alzheimer's disease: Common pathways, common goals.

Authors:  Dean Hartley; Thomas Blumenthal; Maria Carrillo; Gilbert DiPaolo; Lucille Esralew; Katheleen Gardiner; Ann-Charlotte Granholm; Khalid Iqbal; Michael Krams; Cynthia Lemere; Ira Lott; William Mobley; Seth Ness; Ralph Nixon; Huntington Potter; Roger Reeves; Marwan Sabbagh; Wayne Silverman; Benjamin Tycko; Michelle Whitten; Thomas Wisniewski
Journal:  Alzheimers Dement       Date:  2014-12-12       Impact factor: 21.566

6.  A new roadmap for drug development for Alzheimer's disease.

Authors:  Robert E Becker; Nigel H Greig; Ezio Giacobini; Lon S Schneider; Luigi Ferrucci
Journal:  Nat Rev Drug Discov       Date:  2013-12-20       Impact factor: 84.694

7.  Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.

Authors:  Fabio Di Domenico; Raffaella Coccia; Annalisa Cocciolo; M Paul Murphy; Giovanna Cenini; Elizabeth Head; D Allan Butterfield; Alessandra Giorgi; Maria Eugenia Schinina; Cesare Mancuso; Chiara Cini; Marzia Perluigi
Journal:  Biochim Biophys Acta       Date:  2013-04-18

Review 8.  A new regulatory road-map for Alzheimer's disease drug development.

Authors:  Robert E Becker; Nigel H Greig
Journal:  Curr Alzheimer Res       Date:  2014-03       Impact factor: 3.498

9.  The clinical application of array CGH for the detection of chromosomal defects in 20,126 unselected newborns.

Authors:  Sang-Jin Park; Eun Hye Jung; Ran-Suk Ryu; Hyun Woong Kang; He Doo Chung; Ho-Young Kang
Journal:  Mol Cytogenet       Date:  2013-06-01       Impact factor: 2.009

10.  A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease.

Authors:  Hugo Geerts; Patrick Roberts; Athan Spiros; Robert Carr
Journal:  Front Pharmacol       Date:  2013-04-16       Impact factor: 5.810
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