BACKGROUND: Adenoviral infections are endemic in the pediatric population. Most of these infections are mild and self-limited in immunocompetent individuals. Although in profoundly immunocompromised hosts after solid organ or stem cell transplantation, adenovirus may cause fulminant hepatitis or other life-threatening infections, this is a rare complication in patients receiving standard chemotherapy. OBSERVATION: We report a case of severe adenovirus hepatitis in a 7-month-old child receiving induction chemotherapy for hepatoblastoma who fully recovered after treatment with cidofovir. CONCLUSIONS: To our knowledge, this is the first report documenting recovering of severe adenoviral hepatitis in a nontransplanted immunocompromised host.
BACKGROUND:Adenoviral infections are endemic in the pediatric population. Most of these infections are mild and self-limited in immunocompetent individuals. Although in profoundly immunocompromised hosts after solid organ or stem cell transplantation, adenovirus may cause fulminant hepatitis or other life-threatening infections, this is a rare complication in patients receiving standard chemotherapy. OBSERVATION: We report a case of severe adenovirus hepatitis in a 7-month-old child receiving induction chemotherapy for hepatoblastoma who fully recovered after treatment with cidofovir. CONCLUSIONS: To our knowledge, this is the first report documenting recovering of severe adenoviral hepatitis in a nontransplanted immunocompromised host.
Authors: R R Patel; R L Hodinka; A E Kajon; S Klieger; Z Oikonomopoulou; H Petersen; E Rand; E F Attiyeh; B T Fisher Journal: J Pediatric Infect Dis Soc Date: 2013-12-10 Impact factor: 3.164
Authors: Eloy Gonzales-Gustavson; N Timoneda; X Fernandez-Cassi; A Caballero; J F Abril; M Buti; F Rodriguez-Frias; R Girones Journal: PLoS One Date: 2017-10-05 Impact factor: 3.240