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Literature DB >> 22935609

The secrets of the Bcl-2 family.

Abstract

The Bcl-2 family of proteins is formed by pro- and antiapoptotic members. Together they regulate the permeabilization of the mitochondrial outer membrane, a key step in apoptosis. Their complex network of interactions both in the cytosol and on mitochondria determines the fate of the cell. In the past 2 decades, the members of the family have been identified and classified according to their function. Several competing models have been proposed to explain how the Blc-2 proteins orchestrate apoptosis signaling. However, basic aspects of the action of these proteins remain elusive. This review is focused on the biophysical mechanisms that are relevant for their action in apoptosis and on the challenging gaps in our knowledge that necessitate further exploration to finally understand how the Bcl-2 family regulates apoptosis.

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Year: 2012 PMID： 22935609 PMCID： PMC3469065 DOI： 10.1038/cdd.2012.105

Source DB: PubMed Journal: Cell Death Differ ISSN： 1350-9047 Impact factor: 15.828

81 in total

1. Bax forms an oligomer via separate, yet interdependent, surfaces.

Authors: Zhi Zhang; Weijia Zhu; Suzanne M Lapolla; Yiwei Miao; Yuanlong Shao; Mina Falcone; Doug Boreham; Nicole McFarlane; Jingzhen Ding; Arthur E Johnson; Xuejun C Zhang; David W Andrews; Jialing Lin
Journal: J Biol Chem Date: 2010-04-09 Impact factor: 5.157

2. Molecular details of Bax activation, oligomerization, and membrane insertion.

Authors: Stephanie Bleicken; Mirjam Classen; Pulagam V L Padmavathi; Takashi Ishikawa; Kornelius Zeth; Heinz-Jürgen Steinhoff; Enrica Bordignon
Journal: J Biol Chem Date: 2009-12-12 Impact factor: 5.157

3. Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.

Authors: Emily F Eckenrode; Jun Yang; Gopal V Velmurugan; J Kevin Foskett; Carl White
Journal: J Biol Chem Date: 2010-02-26 Impact factor: 5.157

4. Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death.

Authors: Heinrich J Huber; Maike A Laussmann; Jochen H M Prehn; Markus Rehm
Journal: BMC Syst Biol Date: 2010-02-04

Review 5. A guide to super-resolution fluorescence microscopy.

Authors: Lothar Schermelleh; Rainer Heintzmann; Heinrich Leonhardt
Journal: J Cell Biol Date: 2010-07-19 Impact factor: 10.539

6. Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.

Authors: Grant Dewson; Tobias Kratina; Peter Czabotar; Catherine L Day; Jerry M Adams; Ruth M Kluck
Journal: Mol Cell Date: 2009-11-25 Impact factor: 17.970

7. Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid.

Authors: Jun Peng; Jingzhen Ding; Chibing Tan; Bruce Baggenstoss; Zhi Zhang; Suzanne M Lapolla; Jialing Lin
Journal: Apoptosis Date: 2009-10 Impact factor: 4.677

8. Membrane promotes tBID interaction with BCL(XL).

Authors: Ana J García-Sáez; Jonas Ries; Mar Orzáez; Enrique Pérez-Payà; Petra Schwille
Journal: Nat Struct Mol Biol Date: 2009-10-11 Impact factor: 15.369

9. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L).

Authors: L Lindenboim; E Blacher; C Borner; R Stein
Journal: Cell Death Differ Date: 2009-10-09 Impact factor: 15.828

10. Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

Authors: H Düssmann; M Rehm; C G Concannon; S Anguissola; M Würstle; S Kacmar; P Völler; H J Huber; J H M Prehn
Journal: Cell Death Differ Date: 2009-09-11 Impact factor: 15.828

77 in total

1. BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes.

Authors: Zhi Zhang; Sabareesh Subramaniam; Justin Kale; Chenyi Liao; Bo Huang; Hetal Brahmbhatt; Samson G F Condon; Suzanne M Lapolla; Franklin A Hays; Jingzhen Ding; Feng He; Xuejun C Zhang; Jianing Li; Alessandro Senes; David W Andrews; Jialing Lin
Journal: EMBO J Date: 2015-12-23 Impact factor: 11.598

The secrets of the Bcl-2 family.

1. Bax forms an oligomer via separate, yet interdependent, surfaces.

2. Molecular details of Bax activation, oligomerization, and membrane insertion.

3. Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.

4. Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death.

Review 5. A guide to super-resolution fluorescence microscopy.

6. Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.

7. Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid.

8. Membrane promotes tBID interaction with BCL(XL).

9. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L).

10. Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

1. BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes.

Review 2. Computational studies of peptide-induced membrane pore formation.

Review 3. Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis.

4. Topology of active, membrane-embedded Bax in the context of a toroidal pore.

Review 5. Mechanisms regulating neutrophil survival and cell death.

6. Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway.

7. Dietary Calcium Alleviates Fluorine-Induced Liver Injury in Rats by Mitochondrial Apoptosis Pathway.

8. Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival.

9. Src and epidermal growth factor receptor mediate the pro-invasive activity of Bcl-w.

10. Androglobin knockdown inhibits growth of glioma cell lines.