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Literature DB >> 22935535

AMP-activated protein kinase regulation and biological actions in the heart.

Abstract

AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart.

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Year: 2012 PMID： 22935535 PMCID： PMC4397099 DOI： 10.1161/CIRCRESAHA.111.255505

Source DB: PubMed Journal: Circ Res ISSN： 0009-7330 Impact factor: 17.367

151 in total

1. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.

Authors: Thomas Pulinilkunnil; Huamei He; Dong Kong; Kenji Asakura; Odile D Peroni; Anna Lee; Barbara B Kahn
Journal: J Biol Chem Date: 2011-01-05 Impact factor: 5.157

2. Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction.

Authors: Subat Turdi; Machender R Kandadi; Junxing Zhao; Anna F Huff; Min Du; Jun Ren
Journal: J Mol Cell Cardiol Date: 2010-12-16 Impact factor: 5.000

3. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

Authors: Joungmok Kim; Mondira Kundu; Benoit Viollet; Kun-Liang Guan
Journal: Nat Cell Biol Date: 2011-01-23 Impact factor: 28.824

4. Metformin use and mortality in ambulatory patients with diabetes and heart failure.

Authors: David Aguilar; Wenyaw Chan; Biykem Bozkurt; Kumudha Ramasubbu; Anita Deswal
Journal: Circ Heart Fail Date: 2010-10-15 Impact factor: 8.790

5. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways.

Authors: Soojeong Kang; Elie R Chemaly; Roger J Hajjar; Djamel Lebeche
Journal: J Biol Chem Date: 2011-04-08 Impact factor: 5.157

6. Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.

Authors: Vernon W Dolinsky; Anita Y M Chan; Isabelle Robillard Frayne; Peter E Light; Christine Des Rosiers; Jason R B Dyck
Journal: Circulation Date: 2009-03-16 Impact factor: 29.690

7. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure.

Authors: Susheel Gundewar; John W Calvert; Saurabh Jha; Iris Toedt-Pingel; Sang Yong Ji; Denise Nunez; Arun Ramachandran; Mauricio Anaya-Cisneros; Rong Tian; David J Lefer
Journal: Circ Res Date: 2008-12-18 Impact factor: 17.367

8. Regulation of LKB1/STRAD localization and function by E-cadherin.

Authors: Michael Sebbagh; Marie-Josée Santoni; Brian Hall; Jean-Paul Borg; Martin A Schwartz
Journal: Curr Biol Date: 2008-12-24 Impact factor: 10.834

9. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Authors: Daniel F Egan; David B Shackelford; Maria M Mihaylova; Sara Gelino; Rebecca A Kohnz; William Mair; Debbie S Vasquez; Aashish Joshi; Dana M Gwinn; Rebecca Taylor; John M Asara; James Fitzpatrick; Andrew Dillin; Benoit Viollet; Mondira Kundu; Malene Hansen; Reuben J Shaw
Journal: Science Date: 2010-12-23 Impact factor: 47.728

10. Structure of mammalian AMPK and its regulation by ADP.

Authors: Bing Xiao; Matthew J Sanders; Elizabeth Underwood; Richard Heath; Faith V Mayer; David Carmena; Chun Jing; Philip A Walker; John F Eccleston; Lesley F Haire; Peter Saiu; Steven A Howell; Rein Aasland; Stephen R Martin; David Carling; Steven J Gamblin
Journal: Nature Date: 2011-03-13 Impact factor: 49.962

100 in total

Review 1. Clinical Spectrum of PRKAG2 Syndrome.

Authors: Andrea Giuseppe Porto; Francesca Brun; Giovanni Maria Severini; Pasquale Losurdo; Enrico Fabris; Matthew R G Taylor; Luisa Mestroni; Gianfranco Sinagra
Journal: Circ Arrhythm Electrophysiol Date: 2016-01

Review 2. KATP Channels in the Cardiovascular System.

Authors: Monique N Foster; William A Coetzee
Journal: Physiol Rev Date: 2016-01 Impact factor: 37.312

3. Acute and Chronic Increases of Circulating FSTL1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure.

Authors: Mitsuru Seki; Jeffery C Powers; Sonomi Maruyama; Maria A Zuriaga; Chia-Ling Wu; Clara Kurishima; Lydia Kim; Jesse Johnson; Anthony Poidomani; Tao Wang; Eric Muñoz; Sudarsan Rajan; Joon Y Park; Kenneth Walsh; Fabio A Recchia
Journal: Circ Heart Fail Date: 2018-01 Impact factor: 8.790

Review 4. Cardiac metabolism in heart failure: implications beyond ATP production.

Authors: Torsten Doenst; Tien Dung Nguyen; E Dale Abel
Journal: Circ Res Date: 2013-08-30 Impact factor: 17.367

5. Mitochondrial ROS deficiency and diabetic complications: AMP[K]-lifying the adaptation to hyperglycemia.

Authors: Dwight A Towler
Journal: J Clin Invest Date: 2013-10-25 Impact factor: 14.808

6. Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.

Authors: Yuuki Shimizu; Rohini Polavarapu; Kattri-Liis Eskla; Chad K Nicholson; Christopher A Koczor; Rui Wang; William Lewis; Sruti Shiva; David J Lefer; John W Calvert
Journal: J Mol Cell Cardiol Date: 2018-02-03 Impact factor: 5.000

7. The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury.

Authors: Dake Qi; Kwame Atsina; Lintao Qu; Xiaoyue Hu; Xiaohong Wu; Bin Xu; Marta Piecychna; Lin Leng; Günter Fingerle-Rowson; Jiasheng Zhang; Richard Bucala; Lawrence H Young
Journal: J Clin Invest Date: 2014-07-01 Impact factor: 14.808

8. Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart.

Authors: Ji Li; Dake Qi; Haiying Cheng; Xiaoyue Hu; Edward J Miller; Xiaohong Wu; Kerry S Russell; Nicole Mikush; Jiasheng Zhang; Lei Xiao; Robert S Sherwin; Lawrence H Young
Journal: Proc Natl Acad Sci U S A Date: 2013-09-16 Impact factor: 11.205

9. Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome.

Authors: Chang Xie; Ya-Ping Zhang; Lu Song; Jie Luo; Wei Qi; Jialu Hu; Danbo Lu; Zhen Yang; Jian Zhang; Jian Xiao; Bin Zhou; Jiu-Lin Du; Naihe Jing; Yong Liu; Yan Wang; Bo-Liang Li; Bao-Liang Song; Yan Yan
Journal: Cell Res Date: 2016-08-30 Impact factor: 25.617

10. Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.

Authors: Xiaodong Yang; John Mudgett; Ghina Bou-About; Marie-France Champy; Hugues Jacobs; Laurent Monassier; Guillaume Pavlovic; Tania Sorg; Yann Herault; Benoit Petit-Demoulière; Ku Lu; Wen Feng; Hongwu Wang; Li-Jun Ma; Roger Askew; Mark D Erion; David E Kelley; Robert W Myers; Cai Li; Hong-Ping Guan
Journal: J Biol Chem Date: 2016-09-12 Impact factor: 5.157