Literature DB >> 22934707

FAK and Nanog cross talk with p53 in cancer stem cells.

Vita M Golubovskaya1.   

Abstract

This review is focused on the role of Focal Adhesion Kinase (FAK) signaling in cancer stem cells. The recent data demonstrate the important role of FAK in cancer stem cell proliferation, differentiation, motility, and invasion. We showed recently that the transcription factor Nanog binds the FAK promoter and up-regulates FAK expression, and that FAK binds Nanog and phosphorylates it. This review discusses the interaction of FAK, Nanog, Oct-3/4, and Sox-2 signaling pathways that are critical for the regulation of cancer stem cells. The cross-linked signaling of FAK with p53 and Nanog signaling in cancer stem cell and function and targeted therapeutics approaches are discussed.

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Year:  2013        PMID： 22934707      PMCID： PMC3625462          DOI： 10.2174/1871520611313040006

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  46 in total

1.  Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.

Authors:  Ian Chambers; Douglas Colby; Morag Robertson; Jennifer Nichols; Sonia Lee; Susan Tweedie; Austin Smith
Journal:  Cell       Date:  2003-05-30       Impact factor: 41.582

2.  Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

Authors:  S K Hanks; M B Calalb; M C Harper; S K Patel
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

3.  p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression.

Authors:  Tongxiang Lin; Connie Chao; Shin'ichi Saito; Sharlyn J Mazur; Maureen E Murphy; Ettore Appella; Yang Xu
Journal:  Nat Cell Biol       Date:  2004-12-26       Impact factor: 28.824

4.  Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.

Authors:  Vita M Golubovskaya; Richard Finch; William G Cance
Journal:  J Biol Chem       Date:  2005-04-25       Impact factor: 5.157

5.  Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro.

Authors:  Tatyana N Ignatova; Valery G Kukekov; Eric D Laywell; Oleg N Suslov; Frank D Vrionis; Dennis A Steindler
Journal:  Glia       Date:  2002-09       Impact factor: 7.452

6.  A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.

Authors:  T Lapidot; C Sirard; J Vormoor; B Murdoch; T Hoang; J Caceres-Cortes; M Minden; B Paterson; M A Caligiuri; J E Dick
Journal:  Nature       Date:  1994-02-17       Impact factor: 49.962

7.  The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.

Authors:  Kaoru Mitsui; Yoshimi Tokuzawa; Hiroaki Itoh; Kohichi Segawa; Mirei Murakami; Kazutoshi Takahashi; Masayoshi Maruyama; Mitsuyo Maeda; Shinya Yamanaka
Journal:  Cell       Date:  2003-05-30       Impact factor: 41.582

8.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

9.  Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites.

Authors:  Vita Golubovskaya; Aparna Kaur; William Cance
Journal:  Biochim Biophys Acta       Date:  2004-05-25

10.  Identification of human brain tumour initiating cells.

Authors:  Sheila K Singh; Cynthia Hawkins; Ian D Clarke; Jeremy A Squire; Jane Bayani; Takuichiro Hide; R Mark Henkelman; Michael D Cusimano; Peter B Dirks
Journal:  Nature       Date:  2004-11-18       Impact factor: 49.962
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  17 in total

Review 1.  NANOG: a promising target for digestive malignant tumors.

Authors:  Ai-Xi Sun; Chang-Jiang Liu; Zi-Qin Sun; Zhi Wei
Journal:  World J Gastroenterol       Date:  2014-09-28       Impact factor: 5.742

2.  The potential roles of lncRNAs DUXAP8, LINC00963, and FOXD2-AS1 in luminal breast cancer based on expression analysis and bioinformatic approaches.

Authors:  Maedeh Arabpour; Sepideh Mehrpour Layeghi; Javad Tavakkoly Bazzaz; Mohammad Mehdi Naghizadeh; Keivan Majidzadeh-A; Abbas Shakoori
Journal:  Hum Cell       Date:  2021-05-27       Impact factor: 4.174

Review 3.  Insulin Receptor Isoforms in Physiology and Disease: An Updated View.

Authors:  Antonino Belfiore; Roberta Malaguarnera; Veronica Vella; Michael C Lawrence; Laura Sciacca; Francesco Frasca; Andrea Morrione; Riccardo Vigneri
Journal:  Endocr Rev       Date:  2017-10-01       Impact factor: 19.871

4.  Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma.

Authors:  Xiao-Yan Ming; Li Fu; Li-Yi Zhang; Yan-Ru Qin; Ting-Ting Cao; Kwok Wah Chan; Stephanie Ma; Dan Xie; Xin-Yuan Guan
Journal:  Nat Commun       Date:  2016-12-07       Impact factor: 14.919

5.  Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models.

Authors:  Xia Liu; Rokana Taftaf; Madoka Kawaguchi; Ya-Fang Chang; Wenjing Chen; David Entenberg; Youbin Zhang; Lorenzo Gerratana; Simo Huang; Dhwani B Patel; Elizabeth Tsui; Valery Adorno-Cruz; Steven M Chirieleison; Yue Cao; Allison S Harney; Shivani Patel; Antonia Patsialou; Yang Shen; Stefanie Avril; Hannah L Gilmore; Justin D Lathia; Derek W Abbott; Massimo Cristofanilli; John S Condeelis; Huiping Liu
Journal:  Cancer Discov       Date:  2018-10-25       Impact factor: 39.397

6.  Jorunnamycin A Suppresses Stem-Like Phenotypes and Sensitizes Cisplatin-Induced Apoptosis in Cancer Stem-Like Cell-Enriched Spheroids of Human Lung Cancer Cells.

Authors:  Somruethai Sumkhemthong; Supakarn Chamni; Gea U Ecoy; Pornchanok Taweecheep; Khanit Suwanborirux; Eakachai Prompetchara; Pithi Chanvorachote; Chatchai Chaotham
Journal:  Mar Drugs       Date:  2021-05-03       Impact factor: 5.118

7.  Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.

Authors:  Vita M Golubovskaya; Baotran Ho; Min Zheng; Andrew Magis; David Ostrov; Carl Morrison; William G Cance
Journal:  BMC Cancer       Date:  2013-07-11       Impact factor: 4.430

Review 8.  Targeting cancer stem cells: emerging role of Nanog transcription factor.

Authors:  Mong-Lien Wang; Shih-Hwa Chiou; Cheng-Wen Wu
Journal:  Onco Targets Ther       Date:  2013-09-04       Impact factor: 4.147

Review 9.  The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells.

Authors:  Roberta Malaguarnera; Antonino Belfiore
Journal:  Front Endocrinol (Lausanne)       Date:  2014-02-04       Impact factor: 5.555

Review 10.  Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication.

Authors:  Samantha Kaufhold; Hermes Garbán; Benjamin Bonavida
Journal:  J Exp Clin Cancer Res       Date:  2016-05-25
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