BACKGROUND AND PURPOSE: MRI can be used to assess structural damage to the brain after aneurysmal subarachnoid hemorrhage. We tuned, validated, and applied k-Nearest Neighbor-based segmentation to quantify cerebral volumes on MRI 6 months after aneurysmal subarachnoid hemorrhage. METHODS: After tuning, the accuracy of k-Nearest Neighbor-based segmentation was assessed with manual segmentations. Next, supratentorial cerebral parenchymal, peripheral cerebrospinal fluid, and lateral ventricular volumes of 55 patients were compared with those of 25 age- and sex-matched control subjects and related to clinical outcome (modified Rankin Scale). RESULTS: k-Nearest Neighbor-based segmentation showed good agreement with manual segmentations. Compared with control subjects, patients had a larger lateral ventricular volume (difference: log-transformed values 0.54; 95% CI,0.33-0.75), smaller peripheral cerebrospinal fluid volume (-26 mL; 95% CI, -40 to -11), and similar cerebral parenchymal volume (2 mL; 95% CI, -10 to 15). In patients, parenchymal (median split; OR, 38.8; 95% CI, 4.6-329.0) and ventricular volumes (7.4; 95% CI, 1.6-33.5) correlated with functional outcome. CONCLUSIONS: k-Nearest Neighbor-based segmentation provides accurate cerebral volume measurements after aneurysmal subarachnoid hemorrhage. In this proof-of-principle study of this volumetric technique, we demonstrated volume changes relative to controls, which correlated with functional outcome.
BACKGROUND AND PURPOSE: MRI can be used to assess structural damage to the brain after aneurysmal subarachnoid hemorrhage. We tuned, validated, and applied k-Nearest Neighbor-based segmentation to quantify cerebral volumes on MRI 6 months after aneurysmal subarachnoid hemorrhage. METHODS: After tuning, the accuracy of k-Nearest Neighbor-based segmentation was assessed with manual segmentations. Next, supratentorial cerebral parenchymal, peripheral cerebrospinal fluid, and lateral ventricular volumes of 55 patients were compared with those of 25 age- and sex-matched control subjects and related to clinical outcome (modified Rankin Scale). RESULTS: k-Nearest Neighbor-based segmentation showed good agreement with manual segmentations. Compared with control subjects, patients had a larger lateral ventricular volume (difference: log-transformed values 0.54; 95% CI,0.33-0.75), smaller peripheral cerebrospinal fluid volume (-26 mL; 95% CI, -40 to -11), and similar cerebral parenchymal volume (2 mL; 95% CI, -10 to 15). In patients, parenchymal (median split; OR, 38.8; 95% CI, 4.6-329.0) and ventricular volumes (7.4; 95% CI, 1.6-33.5) correlated with functional outcome. CONCLUSIONS: k-Nearest Neighbor-based segmentation provides accurate cerebral volume measurements after aneurysmal subarachnoid hemorrhage. In this proof-of-principle study of this volumetric technique, we demonstrated volume changes relative to controls, which correlated with functional outcome.
Authors: Jeroen de Bresser; Joanna D Schaafsma; Merel J A Luitse; Max A Viergever; Gabriel J E Rinkel; Geert Jan Biessels Journal: Neuroradiology Date: 2014-12-06 Impact factor: 2.804
Authors: Rutger Heinen; Willem H Bouvy; Adrienne M Mendrik; Max A Viergever; Geert Jan Biessels; Jeroen de Bresser Journal: PLoS One Date: 2016-10-31 Impact factor: 3.240
Authors: Sara Khosdelazad; Lieke S Jorna; Rob J M Groen; Sandra E Rakers; Marieke E Timmerman; Ronald J H Borra; Anouk van der Hoorn; Jacoba M Spikman; Anne M Buunk Journal: JMIR Res Protoc Date: 2022-09-29
Authors: Jeroen de Bresser; Hugo J Kuijf; Karlijn Zaanen; Max A Viergever; Jeroen Hendrikse; Geert Jan Biessels Journal: Sci Rep Date: 2018-01-30 Impact factor: 4.379