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Literature DB >> 22933287

Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization.

Philipp Gödel¹, Sonja Windmann, Kirsten K Dietze, Ulf Dittmer, Wibke Bayer.

Abstract

While Friend retrovirus-infected mice readily mount a vigorous CD8(+) T cell response to the leader-gag-derived peptide GagL(85-93), no GagL(85-93)-specific T cells were detectable in mice immunized against Friend virus (FV) with viral vectors or DNA vaccines. By exchanging one epitope-flanking amino acid or using a scaffold protein we were able to demonstrate for the first time the induction of GagL(85-93)-specific CD8(+) T cells by genetic vaccination and show their high protective effect against FV challenge infection.

Entities: Disease Species

Mesh：

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Year: 2012 PMID： 22933287 PMCID： PMC3486454 DOI： 10.1128/JVI.01607-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

26 in total

1. High-capacity adenoviral vectors circumvent the limitations of ΔE1 and ΔE1/ΔE3 adenovirus vectors to induce multispecific transgene product-directed CD8 T-cell responses.

Authors: Matthias W Kron; Tatjana Engler; Erika Schmidt; Reinhold Schirmbeck; Stefan Kochanek; Florian Kreppel
Journal: J Gene Med Date: 2011-12 Impact factor: 4.565

2. Mechanisms of cytokine synergy essential for vaccine protection against viral challenge.

Authors: J D Ahlers; I M Belyakov; S Matsui; J A Berzofsky
Journal: Int Immunol Date: 2001-07 Impact factor: 4.823

3. Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors.

Authors: W Chen; H Qin; B Chesebro; M A Cheever
Journal: J Virol Date: 1996-11 Impact factor: 5.103

4. Expression and co-cytokine function of murine thioredoxin/adult T cell leukaemia-derived factor (ADF).

Authors: H Blum; M Röllinghoff; A Gessner
Journal: Cytokine Date: 1996-01 Impact factor: 3.861

5. Synthesis and glycosylation of polyprotein precursors to the internal core proteins of Friend murine leukemia virus.

Authors: L H Evans; S Dresler; D Kabat
Journal: J Virol Date: 1977-12 Impact factor: 5.103

6. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.

Authors: A Rubartelli; A Bajetto; G Allavena; E Wollman; R Sitia
Journal: J Biol Chem Date: 1992-12-05 Impact factor: 5.157

7. Protection against Friend retrovirus-induced leukemia by recombinant vaccinia viruses expressing the gag gene.

Authors: M Miyazawa; J Nishio; B Chesebro
Journal: J Virol Date: 1992-07 Impact factor: 5.103

8. Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells.

Authors: Marcus Nilsson; Johan Ljungberg; Johan Richter; Thomas Kiefer; Mattias Magnusson; André Lieber; Bengt Widegren; Stefan Karlsson; Xiaolong Fan
Journal: J Gene Med Date: 2004-06 Impact factor: 4.565

9. Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas.

Authors: Koen Schepers; Mireille Toebes; Gitte Sotthewes; Florry A Vyth-Dreese; Trees A M Dellemijn; Cornelis J M Melief; Ferry Ossendorp; Ton N M Schumacher
Journal: J Immunol Date: 2002-09-15 Impact factor: 5.422

10. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function.

Authors: Claes Ohlén; Michael Kalos; Laurence E Cheng; Aaron C Shur; Doley J Hong; Bryan D Carson; Niels C T Kokot; Cara G Lerner; Blythe D Sather; Eric S Huseby; Philip D Greenberg
Journal: J Exp Med Date: 2002-06-03 Impact factor: 14.307

8 in total

1. Comparative Evaluation of the Vaccine Efficacies of Three Adenovirus-Based Vector Types in the Friend Retrovirus Infection Model.

Authors: Camilla Patrizia Hrycak; Sonja Windmann; Wibke Bayer
Journal: J Virol Date: 2019-10-15 Impact factor: 5.103

2. Immunodominance of Adenovirus-Derived CD8⁺ T Cell Epitopes Interferes with the Induction of Transgene-Specific Immunity in Adenovirus-Based Immunization.

Authors: Dominik Schöne; Camilla Patrizia Hrycak; Sonja Windmann; Dennis Lapuente; Ulf Dittmer; Matthias Tenbusch; Wibke Bayer
Journal: J Virol Date: 2017-09-27 Impact factor: 5.103

3. Induction of complex immune responses and strong protection against retrovirus challenge by adenovirus-based immunization depends on the order of vaccine delivery.

Authors: Meike Kaulfuß; Ina Wensing; Sonja Windmann; Camilla Patrizia Hrycak; Wibke Bayer
Journal: Retrovirology Date: 2017-02-06 Impact factor: 4.602

4. Interference of retroviral envelope with vaccine-induced CD8⁺ T cell responses is relieved by co-administration of cytokine-encoding vectors.

Authors: Nadine Bongard; Dennis Lapuente; Sonja Windmann; Ulf Dittmer; Matthias Tenbusch; Wibke Bayer
Journal: Retrovirology Date: 2017-04-27 Impact factor: 4.602

5. Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection.

Authors: Nadine Bongard; Vu Thuy Khanh Le-Trilling; Anna Malyshkina; Meike Rückborn; Kerstin Wohlgemuth; Ina Wensing; Sonja Windmann; Ulf Dittmer; Mirko Trilling; Wibke Bayer
Journal: PLoS Pathog Date: 2019-09-30 Impact factor: 6.823