Literature DB >> 22933279

Enhanced recognition and neutralization of HIV-1 by antibody-derived CCR5-mimetic peptide variants.

Jessica J Chiang1, Matthew R Gardner, Brian D Quinlan, Tatyana Dorfman, Hyeryun Choe, Michael Farzan.   

Abstract

A tyrosine-sulfated CCR5-mimetic peptide, CCR5mim1, inhibits HIV-1 infection more efficiently than sulfopeptides based on the CCR5 amino terminus. Here we characterized sulfopeptide chimeras of CCR5mim1 and the heavy-chain CDR3 of the antibody PG16. Two chimeras bound a range of envelope glycoproteins and neutralized HIV-1 more efficiently than CCR5mim1. An immunoadhesin form of one of these, CCR5mim2-Ig, synergized with CD4-Ig to neutralize HIV-1. These sulfopeptides are among the broadest and most potent CCR5-mimetic peptides described to date.

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Year:  2012        PMID： 22933279      PMCID： PMC3486504          DOI： 10.1128/JVI.00967-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry.

Authors:  M Farzan; N Vasilieva; C E Schnitzler; S Chung; J Robinson; N P Gerard; C Gerard; H Choe; J Sodroski
Journal:  J Biol Chem       Date:  2000-10-27       Impact factor: 5.157

2.  Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120.

Authors:  E G Cormier; M Persuh; D A Thompson; S W Lin; T P Sakmar; W C Olson; T Dragic
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

3.  The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry.

Authors:  Michael Farzan; Gregory J Babcock; Natalya Vasilieva; Paulette L Wright; Enko Kiprilov; Tajib Mirzabekov; Hyeryun Choe
Journal:  J Biol Chem       Date:  2002-05-28       Impact factor: 5.157

4.  The crown and stem of the V3 loop play distinct roles in human immunodeficiency virus type 1 envelope glycoprotein interactions with the CCR5 coreceptor.

Authors:  Emmanuel G Cormier; Tatjana Dragic
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

5.  Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.

Authors:  Hyeryun Choe; Wenhui Li; Paulette L Wright; Natalya Vasilieva; Miro Venturi; Chih-Chin Huang; Christoph Grundner; Tatyana Dorfman; Michael B Zwick; Liping Wang; Eric S Rosenberg; Peter D Kwong; Dennis R Burton; James E Robinson; Joseph G Sodroski; Michael Farzan
Journal:  Cell       Date:  2003-07-25       Impact factor: 41.582

6.  The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.

Authors:  A G Dalgleish; P C Beverley; P R Clapham; D H Crawford; M F Greaves; R A Weiss
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

7.  Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.

Authors:  N Sullivan; Y Sun; J Li; W Hofmann; J Sodroski
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

8.  Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.

Authors:  Laura M Walker; Sanjay K Phogat; Po-Ying Chan-Hui; Denise Wagner; Pham Phung; Julie L Goss; Terri Wrin; Melissa D Simek; Steven Fling; Jennifer L Mitcham; Jennifer K Lehrman; Frances H Priddy; Ole A Olsen; Steven M Frey; Phillip W Hammond; Stephen Kaminsky; Timothy Zamb; Matthew Moyle; Wayne C Koff; Pascal Poignard; Dennis R Burton
Journal:  Science       Date:  2009-09-03       Impact factor: 47.728

9.  The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure.

Authors:  U Moebius; L K Clayton; S Abraham; S C Harrison; E L Reinherz
Journal:  J Exp Med       Date:  1992-08-01       Impact factor: 14.307

10.  Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys.

Authors:  Philip R Johnson; Bruce C Schnepp; Jianchao Zhang; Mary J Connell; Sean M Greene; Eloisa Yuste; Ronald C Desrosiers; K Reed Clark
Journal:  Nat Med       Date:  2009-05-17       Impact factor: 53.440
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  16 in total

1.  A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

Authors:  Devin Sok; Matthias Pauthner; Bryan Briney; Jeong Hyun Lee; Karen L Saye-Francisco; Jessica Hsueh; Alejandra Ramos; Khoa M Le; Meaghan Jones; Joseph G Jardine; Raiza Bastidas; Anita Sarkar; Chi-Hui Liang; Sachin S Shivatare; Chung-Yi Wu; William R Schief; Chi-Huey Wong; Ian A Wilson; Andrew B Ward; Jiang Zhu; Pascal Poignard; Dennis R Burton
Journal:  Immunity       Date:  2016-07-19       Impact factor: 31.745

2.  A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120.

Authors:  Brian D Quinlan; Vinita R Joshi; Matthew R Gardner; Kourosh H Ebrahimi; Michael Farzan
Journal:  J Virol       Date:  2014-01-03       Impact factor: 5.103

3.  Reversible and efficient activation of HIV-1 cell entry by a tyrosine-sulfated peptide dissects endocytic entry and inhibitor mechanisms.

Authors:  Emily J Platt; Michelle M Gomes; David Kabat
Journal:  J Virol       Date:  2014-01-29       Impact factor: 5.103

4.  eCD4-Ig Variants That More Potently Neutralize HIV-1.

Authors:  Ina Fetzer; Matthew R Gardner; Meredith E Davis-Gardner; Neha R Prasad; Barnett Alfant; Jesse A Weber; Michael Farzan
Journal:  J Virol       Date:  2018-05-29       Impact factor: 5.103

5.  A Coreceptor-Mimetic Peptide Enhances the Potency of V3-Glycan Antibodies.

Authors:  Ina Fetzer; Meredith E Davis-Gardner; Matthew R Gardner; Barnett Alfant; Jesse A Weber; Neha R Prasad; Amber S Zhou; Michael Farzan
Journal:  J Virol       Date:  2019-02-19       Impact factor: 5.103

6.  CD4-Induced Antibodies Promote Association of the HIV-1 Envelope Glycoprotein with CD4-Binding Site Antibodies.

Authors:  Matthew R Gardner; Christoph H Fellinger; Neha R Prasad; Amber S Zhou; Hema R Kondur; Vinita R Joshi; Brian D Quinlan; Michael Farzan
Journal:  J Virol       Date:  2016-08-12       Impact factor: 5.103

Review 7.  Systemic and topical use of monoclonal antibodies to prevent the sexual transmission of HIV.

Authors:  Deborah J Anderson; Joseph A Politch; Larry Zeitlin; Andy Hiatt; Kadryn Kadasia; Kenneth H Mayer; Ruth M Ruprecht; Francois Villinger; Kevin J Whaley
Journal:  AIDS       Date:  2017-07-17       Impact factor: 4.632

8.  AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.

Authors:  Matthew R Gardner; Lisa M Kattenhorn; Hema R Kondur; Markus von Schaewen; Tatyana Dorfman; Jessica J Chiang; Kevin G Haworth; Julie M Decker; Michael D Alpert; Charles C Bailey; Ernest S Neale; Christoph H Fellinger; Vinita R Joshi; Sebastian P Fuchs; Jose M Martinez-Navio; Brian D Quinlan; Annie Y Yao; Hugo Mouquet; Jason Gorman; Baoshan Zhang; Pascal Poignard; Michel C Nussenzweig; Dennis R Burton; Peter D Kwong; Michael Piatak; Jeffrey D Lifson; Guangping Gao; Ronald C Desrosiers; David T Evans; Beatrice H Hahn; Alexander Ploss; Paula M Cannon; Michael S Seaman; Michael Farzan
Journal:  Nature       Date:  2015-02-18       Impact factor: 49.962

9.  A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations.

Authors:  Michael Roche; Hamid Salimi; Renee Duncan; Brendan L Wilkinson; Kelechi Chikere; Miranda S Moore; Nicholas E Webb; Helena Zappi; Jasminka Sterjovski; Jacqueline K Flynn; Anne Ellett; Lachlan R Gray; Benhur Lee; Becky Jubb; Mike Westby; Paul A Ramsland; Sharon R Lewin; Richard J Payne; Melissa J Churchill; Paul R Gorry
Journal:  Retrovirology       Date:  2013-04-20       Impact factor: 4.602

10.  Site-selective solid-phase synthesis of a CCR5 sulfopeptide library to interrogate HIV binding and entry.

Authors:  Xuyu Liu; Lara R Malins; Michael Roche; Jasminka Sterjovski; Renee Duncan; Mary L Garcia; Nadine C Barnes; David A Anderson; Martin J Stone; Paul R Gorry; Richard J Payne
Journal:  ACS Chem Biol       Date:  2014-07-24       Impact factor: 5.100
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