Literature DB >> 22933083

Rodent models of experimental autoimmune uveitis.

Rajeev K Agarwal1, Phyllis B Silver, Rachel R Caspi.   

Abstract

The model of experimental autoimmune uveitis (EAU) in mice and in rats is described. EAU targets immunologically privileged retinal antigens and serves as a model of autoimmune uveitis in humans as well as a model for autoimmunity in a more general sense. EAU is a well-characterized, robust, and reproducible model that is easily followed and quantitated. It is inducible with synthetic peptides derived from retinal autoantigens in commonly available strains of rats and mice. The ability to induce EAU in various gene-manipulated, including HLA-transgenic, mouse strains makes the EAU model suitable for the study of basic mechanisms as well as in clinically relevant interventions.

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Year:  2012        PMID： 22933083      PMCID： PMC3810964          DOI： 10.1007/978-1-60761-720-4_22

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  60 in total

1.  Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype.

Authors:  D Avichezer; P B Silver; C C Chan; B Wiggert; R R Caspi
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-01       Impact factor: 4.799

2.  Retinal S antigen identified as the 48K protein regulating light-dependent phosphodiesterase in rods.

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Journal:  Science       Date:  1985-05-17       Impact factor: 47.728

3.  Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice.

Authors:  K Namba; K Ogasawara; N Kitaichi; N Matsuki; A Takahashi; Y Sasamoto; S Kotake; H Matsuda; K Iwabuchi; S Ohno; K Onoé
Journal:  Clin Exp Immunol       Date:  1998-02       Impact factor: 4.330

4.  Autoimmune uveo-retinitis in the rat sensitized with retina photoreceptor cell antigen.

Authors:  W B Wacker; C M Kalsow
Journal:  Int Arch Allergy Appl Immunol       Date:  1973

5.  Alternative routes of immunization for the induction of experimental autoimmune uveoretinitis (EAU) in rodents: a comparison.

Authors:  R M Mozayeni; C C Chan; B G Grubbs; B Wiggert; R R Caspi
Journal:  Ocul Immunol Inflamm       Date:  1995       Impact factor: 3.070

6.  Identification of Bphs, an autoimmune disease locus, as histamine receptor H1.

Authors:  Runlin Z Ma; Jianfeng Gao; Nathan D Meeker; Parley D Fillmore; Kenneth S K Tung; Takeshi Watanabe; James F Zachary; Halina Offner; Elizabeth P Blankenhorn; Cory Teuscher
Journal:  Science       Date:  2002-07-26       Impact factor: 47.728

7.  Human S-antigen: presence of multiple immunogenic and immunopathogenic sites in the Lewis rat.

Authors:  M D de Smet; G Bitar; F G Roberge; I Gery; R B Nussenblatt
Journal:  J Autoimmun       Date:  1993-10       Impact factor: 7.094

8.  Genetic factors in susceptibility and resistance to experimental autoimmune uveoretinitis.

Authors:  R R Caspi; C C Chan; Y Fujino; S Oddo; F Najafian; S Bahmanyar; H Heremans; R L Wilder; B Wiggert
Journal:  Curr Eye Res       Date:  1992       Impact factor: 2.424

9.  Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype.

Authors:  Jun Tang; Wei Zhu; Phyllis B Silver; Shao-Bo Su; Chi-Chao Chan; Rachel R Caspi
Journal:  J Immunol       Date:  2007-05-01       Impact factor: 5.422

10.  Regulation of experimental autoimmune uveitis in rats--separation of MHC and non-MHC gene effects.

Authors:  S Hirose; K Ogasawara; T Natori; Y Sasamoto; S Ohno; H Matsuda; K Onoé
Journal:  Clin Exp Immunol       Date:  1991-12       Impact factor: 4.330
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  69 in total

1.  The cAMP-Adenosine Feedback Loop Maintains the Suppressive Function of Regulatory T Cells.

Authors:  Wenru Su; Xiaoqing Chen; Wenjie Zhu; Jianfeng Yu; Weihua Li; Yingqi Li; Zhuang Li; Nancy Olsen; Dan Liang; Song Guo Zheng
Journal:  J Immunol       Date:  2019-08-16       Impact factor: 5.422

Review 2.  Autoimmune uveitis: clinical, pathogenetic, and therapeutic features.

Authors:  Marcella Prete; Rosanna Dammacco; Maria Celeste Fatone; Vito Racanelli
Journal:  Clin Exp Med       Date:  2015-03-28       Impact factor: 3.984

3.  Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing.

Authors:  Jacob S Heng; Sean F Hackett; Genevieve L Stein-O'Brien; Briana L Winer; John Williams; Loyal A Goff; Jeremy Nathans
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-16       Impact factor: 11.205

4.  Complement-Mediated Activation of the NLRP3 Inflammasome and Its Inhibition by AAV-Mediated Delivery of CD59 in a Model of Uveitis.

Authors:  Binit Kumar; Siobhan M Cashman; Rajendra Kumar-Singh
Journal:  Mol Ther       Date:  2018-03-19       Impact factor: 11.454

Review 5.  Biologic agents in experimental autoimmune uveitis.

Authors:  Gian Paolo Giuliari; Ama Sadaka; David M Hinkle
Journal:  Int Ophthalmol       Date:  2013-03-14       Impact factor: 2.031

6.  Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype.

Authors:  Mary J Mattapallil; Phyllis B Silver; Lizette M Cortes; Anthony J St Leger; Yingyos Jittayasothorn; Jennifer L Kielczewski; James J Moon; Chi-Chao Chan; Rachel R Caspi
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-08       Impact factor: 4.799

7.  Immunological and pathological investigations in equine experimental uveitis.

Authors:  Galina P Simeonova; Svetozar Z Krastev; Radostin S Simeonov
Journal:  Vet Res Commun       Date:  2016-06-25       Impact factor: 2.459

8.  Comparative Proteomic Analysis of Two Uveitis Models in Lewis Rats.

Authors:  Kathryn L Pepple; Lauren Rotkis; Leslie Wilson; Angela Sandt; Russell N Van Gelder
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-12       Impact factor: 4.799

9.  Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice.

Authors:  Xiangda Meng; Sijie Fang; Zhuhong Zhang; Yang Wang; Caiyun You; Jingkai Zhang; Hua Yan
Journal:  Cell Mol Immunol       Date:  2016-03-21       Impact factor: 11.530

10.  Vorinostat Modulates the Imbalance of T Cell Subsets, Suppresses Macrophage Activity, and Ameliorates Experimental Autoimmune Uveoretinitis.

Authors:  Sijie Fang; Xiangda Meng; Zhuhong Zhang; Yang Wang; Yuanyuan Liu; Caiyun You; Hua Yan
Journal:  Neuromolecular Med       Date:  2016-01-21       Impact factor: 3.843
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