Literature DB >> 22933

Dopaminergic inhibition of adrenergic neurotransmission as a model for studies on dopamine receptor mechanisms.

O S Steinsland, J P Hieble.   

Abstract

Dopamine and apomorphine produced concentration-dependent inhibition of adrenergic neurotransmission in the isolated, perfused, rabbit ear artery. The inhibitory action of both dopamine and apomorphine was competitively antagonized by haloperidol and several other antipsychotic drugs. The calculated affinities of these drugs for the dopaminergic receptor correlate closely with both the pharmacological potencies of these drugs in vivo and their reported potencies as inhibitors of [3H]haloperidol binding to "dopamine receptors" in brain homogenates.

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Year:  1978        PMID： 22933     DOI： 10.1126/science.22933

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  Effects of continuous and acute administration of small doses of apomorphine, alone or in combination with chlorpromazine, on the brain monoamines and free amino acid levels in the rat.

Authors:  H Koyuncuoğlu; S Atamer-Simşek; M Keyer-Uysal
Journal:  Psychopharmacology (Berl)       Date:  1979-11       Impact factor: 4.530

2.  Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists.

Authors:  L Edvinsson; J McCulloch; J Sharkey
Journal:  Br J Pharmacol       Date:  1985-06       Impact factor: 8.739

3.  Biomolecular information analysis in neurotransmitter systems.

Authors:  S C Brooks
Journal:  Acta Biotheor       Date:  1984       Impact factor: 1.774

4.  Comparison of central and peripheral alpha 1-adrenoceptors.

Authors:  J P Hieble; H M Sarau; J J Foley; R M Demarinis; R G Pendleton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-03       Impact factor: 3.000

5.  Circadian variation in plasma dopamine levels in man.

Authors:  J R Sowers; N Vlachakis
Journal:  J Endocrinol Invest       Date:  1984-08       Impact factor: 4.256

6.  Increased forearm vascular resistance after dopamine blockade.

Authors:  D Mannering; E D Bennett; N Mehta; F Kemp
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

7.  Effects of ring substitution on the pre- and postjunctional alpha-adrenergic activity of aryliminoimidazolidines.

Authors:  J P Hieble; R G Pendleton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-11       Impact factor: 3.000

8.  Dopaminergic control of gastric mucosal blood flow in humans. A study with endoscopic laser Doppler flowmetry coupled with gastric submucosal drug injection.

Authors:  M Kaise; H Echizen; T Ishizaki
Journal:  Dig Dis Sci       Date:  1993-07       Impact factor: 3.199

9.  The role of presynaptic receptors in the cardiovascular actions of N,N-di-n-propyldopamine in the cat and dog.

Authors:  R Massingham; M L Dubocovich; S Z Langer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-10       Impact factor: 3.000

10.  Inhibitory effect of dopamine on canine gastric fundus.

Authors:  R A Lefebvre; J L Willems; M G Bogaert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-05       Impact factor: 3.000
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