Literature DB >> 22932884

Determinants of uterine aging: lessons from rodent models.

ShuangBo Kong1, Shuang Zhang, YongJie Chen, WeiXiang Wang, BingYan Wang, Qi Chen, EnKui Duan, HaiBin Wang.   

Abstract

The uterus is an indispensable organ for the development of a new life in eutherian mammals. The female mammalian reproductive capacity diminishes with age. In this respect, the senescence of uterine endometrium is convinced to contribute to this failure. This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models. A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.

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Year:  2012        PMID： 22932884     DOI： 10.1007/s11427-012-4356-1

Source DB:  PubMed          Journal:  Sci China Life Sci        ISSN： 1674-7305            Impact factor:   6.038


  7 in total

1.  Expression of bone morphogenetic protein 2, 4, and related components of the BMP signaling pathway in the mouse uterus during the estrous cycle.

Authors:  Yan Li; Quan-wei Wei; Jian-gang Feng; Mu-lin Xu; Rui-hua Huang; Fang-xiong Shi
Journal:  J Zhejiang Univ Sci B       Date:  2014-07       Impact factor: 3.066

2.  Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers.

Authors:  Shani Stern; David Biron; Elisha Moses
Journal:  BMC Genet       Date:  2016-07-11       Impact factor: 2.797

3.  Decidualisation and placentation defects are a major cause of age-related reproductive decline.

Authors:  Laura Woods; Vicente Perez-Garcia; Jens Kieckbusch; Xiaoqiu Wang; Francesco DeMayo; Francesco Colucci; Myriam Hemberger
Journal:  Nat Commun       Date:  2017-09-05       Impact factor: 14.919

4.  Effect of reproductive ageing on pregnant mouse uterus and cervix.

Authors:  Rima Patel; James D Moffatt; Evangelia Mourmoura; Luc Demaison; Paul T Seed; Lucilla Poston; Rachel M Tribe
Journal:  J Physiol       Date:  2017-02-08       Impact factor: 5.182

5.  Sex Differences in Adipose Tissue CD8+ T Cells and Regulatory T Cells in Middle-Aged Mice.

Authors:  Hilda Ahnstedt; Meaghan Roy-O'Reilly; Monica S Spychala; Alexis S Mobley; Javiera Bravo-Alegria; Anjali Chauhan; Jaroslaw Aronowski; Sean P Marrelli; Louise D McCullough
Journal:  Front Immunol       Date:  2018-04-04       Impact factor: 7.561

Review 6.  The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions.

Authors:  Laura Secomandi; Michela Borghesan; Michael Velarde; Marco Demaria
Journal:  Hum Reprod Update       Date:  2022-02-28       Impact factor: 15.610

7.  Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice.

Authors:  Marcelo B Cavalcante; Tatiana D Saccon; Allancer D C Nunes; James L Kirkland; Tamara Tchkonia; Augusto Schneider; Michal M Masternak
Journal:  Aging (Albany NY)       Date:  2020-01-18       Impact factor: 5.682
  7 in total

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