Literature DB >> 22932748

A randomized clinical trial of lithium in multiple system atrophy.

Francesco Saccà1, Angela Marsili, Mario Quarantelli, Vincenzo Brescia Morra, Arturo Brunetti, Rosa Carbone, Chiara Pane, Giorgia Puorro, Cinzia Valeria Russo, Elena Salvatore, Tecla Tucci, Giuseppe De Michele, Alessandro Filla.   

Abstract

The aim of our study was to test the safety and tolerability of lithium in multiple system atrophy (MSA). The study was randomized, placebo-controlled, and double-blind. The primary endpoint of the study was safety and tolerability. An interim analysis, performed 1 year after the first patient was randomized, showed a higher proportion of trial abandon (P < 0.01) and a higher number of adverse events (P < 0.02) in the lithium group. The trial was stopped by the Data Monitoring Committee. Overall, lithium was not well tolerated, and we do not encourage future studies with lithium in MSA patients.

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Year:  2012        PMID： 22932748     DOI： 10.1007/s00415-012-6655-7

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


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