Dangsheng Huang1, Ming Han, Yang Xie. 1. Second People's Hospital of Jieyang Dongshan District, Jieyang, China. dangsheng120@sohu.com
Abstract
OBJECTIVE: To investigate the value of serum inflammatory markers in the diagnosis of acute appendicitis (AA) in children. METHODS: Blood samples were collected from 51 children with AA and 16 children with nonsurgical abdominal pain (NSAP) to examine white blood cell count (WBC), serum C-reactive protein (CRP), interleukin-6, and tumor necrosis factor-α (TNF-α). RESULTS: WBC count, CRP, IL-6 and TNF-α increased significantly in children with severe AA (phlegmonous or gangrenous, and perforated appendicitis). ROC curves showed that IL-6 or TNF-α had a greater contribution than WBC count to the diagnosis of severe appendicitis. CONCLUSION: IL-6 and TNF-α can provide complementary information to assist the clinical decision of emergency operation for children with AA.
OBJECTIVE: To investigate the value of serum inflammatory markers in the diagnosis of acute appendicitis (AA) in children. METHODS: Blood samples were collected from 51 children with AA and 16 children with nonsurgical abdominal pain (NSAP) to examine white blood cell count (WBC), serum C-reactive protein (CRP), interleukin-6, and tumor necrosis factor-α (TNF-α). RESULTS: WBC count, CRP, IL-6 and TNF-α increased significantly in children with severe AA (phlegmonous or gangrenous, and perforated appendicitis). ROC curves showed that IL-6 or TNF-α had a greater contribution than WBC count to the diagnosis of severe appendicitis. CONCLUSION:IL-6 and TNF-α can provide complementary information to assist the clinical decision of emergency operation for children with AA.