Literature DB >> 22931528

Histamine H3 receptor function and ligands: recent developments.

Mahaveer Singh1, Hemant R Jadhav.   

Abstract

Histamine H3 receptors are found mostly in central nervous system involved in the regulation of release of various neurotransmitters in brain. They have been implicated in diverse potential therapeutic applications such as sleep-wake disorders, attention-deficient hyperactivity disorder, epilepsy, cognitive impairment and obesity. This review is an attempt to elucidate the function of H3 receptors and their role in various CNS disorders. Also, it is aimed at collating the information on efforts of various medicinal chemists to synthesize the H3 receptor agonists and antagonists in single article.

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Year:  2013        PMID： 22931528

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  10 in total

Review 1.  Histamine H₄ receptors in the gastrointestinal tract.

Authors:  A Deiteren; J G De Man; P A Pelckmans; B Y De Winter
Journal:  Br J Pharmacol       Date:  2015-01-12       Impact factor: 8.739

2.  Biphenyl-ethyl-pyrrolidine derivatives as histamine h3 receptor modulators for the treatment of cognitive disorders.

Authors:  Benjamin Blass
Journal:  ACS Med Chem Lett       Date:  2015-02-06       Impact factor: 4.345

Review 3.  Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

Authors:  Mohammad A Khanfar; Anna Affini; Kiril Lutsenko; Katarina Nikolic; Stefania Butini; Holger Stark
Journal:  Front Neurosci       Date:  2016-05-30       Impact factor: 4.677

4.  Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

Authors:  Michael A Letavic; Leah Aluisio; Richard Apodaca; Manoj Bajpai; Ann J Barbier; Anne Bonneville; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Ian C Fraser; Michelle L Kramer; Brian Lord; Timothy W Lovenberg; Lilian Y Li; Kiev S Ly; Heather Mcallister; Neelakandha S Mani; Kirsten L Morton; Anthony Ndifor; S Diane Nepomuceno; Chennagiri R Pandit; Steven B Sands; Chandra R Shah; Jonathan E Shelton; Sandra S Snook; Devin M Swanson; Wei Xiao
Journal:  ACS Med Chem Lett       Date:  2015-03-13       Impact factor: 4.345

5.  Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.

Authors:  Fouad H Darras; Steffen Pockes; Guozheng Huang; Sarah Wehle; Andrea Strasser; Hans-Joachim Wittmann; Martin Nimczick; Christoph A Sotriffer; Michael Decker
Journal:  ACS Chem Neurosci       Date:  2014-01-14       Impact factor: 4.418

Review 6.  Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.

Authors:  Natalia Guzior; Anna Wieckowska; Dawid Panek; Barbara Malawska
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

Review 7.  The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets.

Authors:  Elden Berla Thangam; Ebenezer Angel Jemima; Himadri Singh; Mirza Saqib Baig; Mahejibin Khan; Clinton B Mathias; Martin K Church; Rohit Saluja
Journal:  Front Immunol       Date:  2018-08-13       Impact factor: 7.561

8.  Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress.

Authors:  Frédéric Chauveau; Elodie De Job; Betty Poly-Thomasson; Raphaël Cavroy; Julien Thomasson; Dominique Fromage; Daniel Beracochea
Journal:  CNS Neurosci Ther       Date:  2019-05-15       Impact factor: 5.243

9.  Synthesis and characterization of new bivalent agents as melatonin- and histamine H3-ligands.

Authors:  Daniele Pala; Laura Scalvini; Alessio Lodola; Marco Mor; Lisa Flammini; Elisabetta Barocelli; Valeria Lucini; Francesco Scaglione; Silvia Bartolucci; Annalida Bedini; Silvia Rivara; Gilberto Spadoni
Journal:  Int J Mol Sci       Date:  2014-09-12       Impact factor: 5.923

10.  Effects of histamine and various histamine receptor antagonists on gene expression profiles of macrophages during compressive strain.

Authors:  Agnes Schröder; Catharina Petring; Anna Damanaki; Jonathan Jantsch; Peter Proff; Christian Kirschneck
Journal:  J Orofac Orthop       Date:  2021-07-06       Impact factor: 2.341
  10 in total

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