Literature DB >> 22931417

Quinones derived from plant secondary metabolites as anti-cancer agents.

Jin-Jian Lu1, Jiao-Lin Bao, Guo-Sheng Wu, Wen-Shan Xu, Ming-Qing Huang, Xiu-Ping Chen, Yi-Tao Wang.   

Abstract

Quinones are plant-derived secondary metabolites that present some anti-proliferation and anti-metastasis effects in various cancer types both in vitro and in vivo. This review focuses on the anti-cancer prospects of plant-derived quinones, namely, aloe-emodin, juglone, β-lapachol, plumbagin, shikonin, and thymoquinone. We intend to summarize their anti-cancer effects and investigate the mechanism of actions to promote the research and development of anti-cancer agents from quinones.

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Year:  2013        PMID： 22931417

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  25 in total

1.  Characterization of lapachol cytotoxicity: contribution of glutathione depletion for oxidative stress in Saccharomyces cerevisiae.

Authors:  Frederico A V Castro; Gabriel F M de Souza; Marcos D Pereira
Journal:  Folia Microbiol (Praha)       Date:  2019-06-11       Impact factor: 2.099

2.  One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl)anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities.

Authors:  Li-Ming Zhao; Feng-Xia Cao; Hai-Shan Jin; Jie-Huan Zhang; Jeffrey Szwaya; Guangdi Wang
Journal:  Bioorg Med Chem Lett       Date:  2016-04-06       Impact factor: 2.823

3.  New Hybrids Derived from Podophyllic Aldehyde and Diterpenylhydroquinones with Selectivity toward Osteosarcoma Cells.

Authors:  Ángela P Hernández; Paula Díez; Pablo A García; José M Miguel Del Corral; Martín Pérez-Andrés; David Díez; Arturo San Feliciano; Manuel Fuentes; Ma Ángeles Castro
Journal:  ACS Med Chem Lett       Date:  2018-03-08       Impact factor: 4.345

4.  Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells.

Authors:  Ting Li; Xiao-huang Xu; Zheng-hai Tang; Ya-fang Wang; Chung-hang Leung; Dik-lung Ma; Xiu-ping Chen; Yi-tao Wang; Yi Chen; Jin-jian Lu
Journal:  Acta Pharmacol Sin       Date:  2015-11-23       Impact factor: 6.150

5.  β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling.

Authors:  Dan Lu; Jing Qian; Wei Li; Qianqian Feng; Shu Pan; Siquan Zhang
Journal:  Oncol Lett       Date:  2015-09-30       Impact factor: 2.967

6.  High-throughput screen of natural product libraries for hsp90 inhibitors.

Authors:  Jason Davenport; Maurie Balch; Lakshmi Galam; Antwan Girgis; Jessica Hall; Brian S J Blagg; Robert L Matts
Journal:  Biology (Basel)       Date:  2014-02-10

7.  Triggering of programmed erythrocyte death by alantolactone.

Authors:  Kousi Alzoubi; Salvatrice Calabrò; Jasmin Egler; Caterina Faggio; Florian Lang
Journal:  Toxins (Basel)       Date:  2014-12-22       Impact factor: 4.546

8.  Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study.

Authors:  Jiaolin Bao; Fang Liu; Chao Zhang; Kai Wang; Xuejing Jia; Xiaotong Wang; Meiwan Chen; Peng Li; Huanxing Su; Yitao Wang; Jian-Bo Wan; Chengwei He
Journal:  Sci Rep       Date:  2016-12-19       Impact factor: 4.379

9.  Aloe-emodin suppresses hypoxia-induced retinal angiogenesis via inhibition of HIF-1α/VEGF pathway.

Authors:  Jianming Wu; Xiao Ke; Wei Wang; Hongcheng Zhang; Na Ma; Wei Fu; Manxi Zhao; Xiaoping Gao; Xiaofeng Hao; Zhirong Zhang
Journal:  Int J Biol Sci       Date:  2016-10-25       Impact factor: 6.580

10.  Plumbagin reduces human colon cancer cell survival by inducing cell cycle arrest and mitochondria-mediated apoptosis.

Authors:  Binil Eldhose; Mia Gunawan; Mahbubur Rahman; Mukalel S Latha; Vicente Notario
Journal:  Int J Oncol       Date:  2014-08-08       Impact factor: 5.650
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