Literature DB >> 2293102

Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2.

V K Singh1, S J Leu.   

Abstract

Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

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Year:  1990        PMID： 2293102     DOI： 10.1016/0304-3940(90)90025-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  25 in total

1.  Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes.

Authors:  Eric M Smith; Mike Gregg; Farhad Hashemi; Liesl Schott; Thomas K Hughes
Journal:  Cell Mol Neurobiol       Date:  2006-04-22       Impact factor: 5.046

2.  Intrapituitary cytokines in Cushing's disease: do they play a role?

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Journal:  Pituitary       Date:  2011-09       Impact factor: 4.107

Review 3.  Psychological stress in IBD: new insights into pathogenic and therapeutic implications.

Authors:  J E Mawdsley; D S Rampton
Journal:  Gut       Date:  2005-10       Impact factor: 23.059

Review 4.  Psychological aspects of inflammatory bowel disease.

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Journal:  J Gastroenterol       Date:  2007-01       Impact factor: 7.527

5.  Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis.

Authors:  Eric M Smith
Journal:  Brain Behav Immun       Date:  2007-09-27       Impact factor: 7.217

Review 6.  Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications.

Authors:  M Larauche; C Kiank; Y Tache
Journal:  J Physiol Pharmacol       Date:  2009-12       Impact factor: 3.011

7.  Alpha-melanocyte-stimulating hormone attenuates behavioral effects of corticotropin-releasing factor in isolated guinea pig pups.

Authors:  Patricia A Schiml-Webb; Emily Miller; Terrence Deak; Michael B Hennessy
Journal:  Dev Psychobiol       Date:  2009-07       Impact factor: 3.038

Review 8.  Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors.

Authors:  Cornelia Kiank; Yvette Taché; Muriel Larauche
Journal:  Brain Behav Immun       Date:  2009-08-19       Impact factor: 7.217

9.  Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis.

Authors:  L J Crofford; H Sano; K Karalis; E L Webster; E A Goldmuntz; G P Chrousos; R L Wilder
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

Review 10.  Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach.

Authors:  Nadja Tariverdian; Theoharis C Theoharides; Friederike Siedentopf; Gabriela Gutiérrez; Udo Jeschke; Gabriel A Rabinovich; Sandra M Blois; Petra C Arck
Journal:  Semin Immunopathol       Date:  2007-06       Impact factor: 9.623
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