Literature DB >> 2293095

Tetanus toxin-induced seizures cause microglial activation in rat hippocampus.

J A Shaw1, V H Perry, J Mellanby.   

Abstract

Tetanus toxin (about 20 mouse LD50) injected into the ventral hippocampus of rats leads to brief seizures occurring intermittently over a period of weeks. Toxin injection leads to the appearance of activated microglia (detected with OX42 immunohistochemistry) in the hippocampus. After 7-14 days, many activated microglia are visible in CA1 area of dorsal hippocampus aligned with the pyramidal cell dendrites and having the morphology characteristic of 'rod cells'. Extensive cell loss is found in dorsal CA1, but not at the injection site, in about one third of injected rats.

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Year:  1990        PMID： 2293095     DOI： 10.1016/0304-3940(90)90169-a

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  11 in total

1.  Gliosis in the mouse hippocampus without neuronal death after systemic administration of high dosage of tetanus toxin.

Authors:  Seung Min Park; Bing Chun Yan; Joon Ha Park; Jung Hoon Choi; Ki-Yeon Yoo; Choong Hyun Lee; Yi-Young Baek; Young-Myeong Kim; Il-Jun Kang; Moo-Ho Won
Journal:  Cell Mol Neurobiol       Date:  2011-12-03       Impact factor: 5.046

2.  Chronological changes in inflammatory cytokines immunoreactivities in the mouse hippocampus after systemic administration of high dosage of tetanus toxin.

Authors:  Bing Chun Yan; Joon Ha Park; In Hye Kim; Bich Na Shin; Ji Hyeon Ahn; Ki-Yeon Yoo; Deuk-Sik Lee; Myong Jo Kim; Il-Jun Kang; Moo-Ho Won
Journal:  Exp Brain Res       Date:  2012-09-19       Impact factor: 1.972

Review 3.  Chronic focal epilepsy induced by intracerebral tetanus toxin.

Authors:  J G Jefferys; C Borck; J Mellanby
Journal:  Ital J Neurol Sci       Date:  1995 Feb-Mar

4.  Loss of hilar somatostatin neurons following tetanus toxin-induced seizures.

Authors:  J Mitchell; M Gatherer; L E Sundstrom
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

Review 5.  Domoic acid-induced neurotoxicity in the hippocampus of adult rats.

Authors:  Ananth Chandrasekaran; Gopalakrishnakone Ponnambalam; Charanjit Kaur
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

6.  Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy.

Authors:  Premysl Jiruska; Gerald T Finnerty; Andrew D Powell; Noosheen Lofti; Roman Cmejla; John G R Jefferys
Journal:  Brain       Date:  2010-04-16       Impact factor: 13.501

7.  Increased expression of GAD mRNA during the chronic epileptic syndrome due to intrahippocampal tetanus toxin.

Authors:  A Najlerahim; S F Williams; R C Pearson; J G Jefferys
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

8.  Activation and re-expression of surface antigen in microglia following an epidural application of kainic acid in the rat brain.

Authors:  C Kaur; E A Ling
Journal:  J Anat       Date:  1992-04       Impact factor: 2.610

9.  Systemic administration of low dosage of tetanus toxin decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus.

Authors:  Bing Chun Yan; In Hye Kim; Joon Ha Park; Ji Hyeon Ahn; Jeong-Hwi Cho; Bai Hui Chen; Jae-Chul Lee; Jung Hoon Choi; Ki-Yeon Yoo; Choong Hyun Lee; Jun Hwi Cho; Jong-Dai Kim; Moo-Ho Won
Journal:  Lab Anim Res       Date:  2013-09-27

10.  Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.

Authors:  M Nieto-Rostro; G Sandhu; C S Bauer; P Jiruska; J G R Jefferys; A C Dolphin
Journal:  Neuroscience       Date:  2014-03-15       Impact factor: 3.590
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