OBJECTIVE: To analyse the relationship between objectively measured daily walking duration and cardiovascular biomarkers of inflammation, cardiac dysfunction and renal impairment. METHODS: Between March 2009 and April 2010, physical activity was assessed in 1253 community-dwelling individuals living in Germany aged ≥65 years (57% men) over 1 week using a thigh-worn accelerometer. C reactive protein (CRP), white blood cells (WBC), N-terminal pro-brain natriuretic peptide, high-sensitive troponin T (hsTnT), creatinine (Cr) and cystatin C (CysC) were also measured. Least-square means of daily walking duration were calculated for quartiles of each biomarker adjusted for sex, age, pre-existing cardiovascular disease and smoking status. RESULTS: After adjustment for covariates, statistically significant linear associations with walking duration were observed for WBC, hsTnT, Cr and CysC. CRP quartiles 1 and 2 showed no significant difference followed by a significant inverse dose-response relationship. A similar pattern, but less pronounced, was seen for N-terminal pro-brain natriuretic peptide. Mean differences between the first two quartiles of CRP and its fourth quartile were 17 min. Between categories 1 (more beneficial) and 4 of WBC, hsTnT, Cr and CysC the differences were 15, 12, 23 and 20 min, respectively. CONCLUSION: Increased walking duration is associated with a more favourable profile of cardiovascular biomarkers in elderly subjects.
OBJECTIVE: To analyse the relationship between objectively measured daily walking duration and cardiovascular biomarkers of inflammation, cardiac dysfunction and renal impairment. METHODS: Between March 2009 and April 2010, physical activity was assessed in 1253 community-dwelling individuals living in Germany aged ≥65 years (57% men) over 1 week using a thigh-worn accelerometer. C reactive protein (CRP), white blood cells (WBC), N-terminal pro-brain natriuretic peptide, high-sensitive troponin T (hsTnT), creatinine (Cr) and cystatin C (CysC) were also measured. Least-square means of daily walking duration were calculated for quartiles of each biomarker adjusted for sex, age, pre-existing cardiovascular disease and smoking status. RESULTS: After adjustment for covariates, statistically significant linear associations with walking duration were observed for WBC, hsTnT, Cr and CysC. CRP quartiles 1 and 2 showed no significant difference followed by a significant inverse dose-response relationship. A similar pattern, but less pronounced, was seen for N-terminal pro-brain natriuretic peptide. Mean differences between the first two quartiles of CRP and its fourth quartile were 17 min. Between categories 1 (more beneficial) and 4 of WBC, hsTnT, Cr and CysC the differences were 15, 12, 23 and 20 min, respectively. CONCLUSION: Increased walking duration is associated with a more favourable profile of cardiovascular biomarkers in elderly subjects.
Authors: Michael L Alosco; Adam M Brickman; Mary Beth Spitznagel; Lawrence H Sweet; Richard Josephson; Erica Y Griffith; Atul Narkhede; Joel Hughes; John Gunstad Journal: J Int Neuropsychol Soc Date: 2015-11 Impact factor: 2.892
Authors: Laith I Alshawabkeh; Laura M Yee; Julius M Gardin; John S Gottdiener; Michelle C Odden; Traci M Bartz; Alice M Arnold; Kenneth J Mukamal; Robert B Wallace Journal: J Am Heart Assoc Date: 2015-04-23 Impact factor: 5.501
Authors: Barbara J Jefferis; Peter H Whincup; Lucy T Lennon; Olia Papacosta; S Goya Wannamethee Journal: J Am Geriatr Soc Date: 2014-03-17 Impact factor: 5.562
Authors: Noreen van der Linden; Lieke J J Klinkenberg; Marika Leenders; Michael Tieland; Lex B Verdijk; Marijke Niens; Jeroen D E van Suijlen; Lisette C P G M de Groot; Otto Bekers; Luc J C van Loon; Marja P van Dieijen-Visser; Steven J R Meex Journal: Sci Rep Date: 2015-12-16 Impact factor: 4.379