Literature DB >> 22930560

Structure-activity relationships of a novel group of large-conductance Ca(2+)-activated K(+) (BK) channel modulators: the GoSlo-SR family.

Subhrangsu Roy1, Adebola Morayo Akande, Roddy J Large, Tim I Webb, Costin Camarasu, Gerard P Sergeant, Noel G McHale, Keith D Thornbury, Mark A Hollywood.   

Abstract

Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels were examined and, as shown, shifted voltage dependent activation >-100 mV (at 10 μM). They were more efficacious than NS11021 and could provide a new scaffold for the design of efficacious BK openers.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22930560     DOI： 10.1002/cmdc.201200321

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  13 in total

Review 1.  2014 Conway review lecture, Royal Academy of Medicine in Ireland: “S6, drugs and RCK and Bowl”.

Authors:  M A Hollywood
Journal:  Ir J Med Sci       Date:  2016-02       Impact factor: 1.568

2.  Effects of the novel BK (KCa 1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BKβ subunits.

Authors:  R J Large; A Kshatri; T I Webb; S Roy; A Akande; E Bradley; G P Sergeant; K D Thornbury; N G McHale; M A Hollywood
Journal:  Br J Pharmacol       Date:  2015-03-26       Impact factor: 8.739

3.  Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.

Authors:  Timothy I Webb; Aravind Singh Kshatri; Roddy J Large; Adebola Morayo Akande; Subhrangsu Roy; Gerard P Sergeant; Noel G McHale; Keith D Thornbury; Mark A Hollywood
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-04       Impact factor: 11.205

4.  NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

Authors:  Bernhard Nausch; Frederik Rode; Susanne Jørgensen; Antonio Nardi; Mads P G Korsgaard; Charlotte Hougaard; Adrian D Bonev; William D Brown; Tino Dyhring; Dorte Strøbæk; Søren-Peter Olesen; Palle Christophersen; Morten Grunnet; Mark T Nelson; Lars C B Rønn
Journal:  J Pharmacol Exp Ther       Date:  2014-06-20       Impact factor: 4.030

5.  Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1-4 channels.

Authors:  Aravind S Kshatri; Qin Li; Jiusheng Yan; Roddy J Large; Gerard P Sergeant; Noel G McHale; Keith D Thornbury; Mark A Hollywood
Journal:  Channels (Austin)       Date:  2016-07-20       Impact factor: 2.581

6.  A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.

Authors:  Marcus Schewe; Han Sun; Ümit Mert; Alexandra Mackenzie; Ashley C W Pike; Friederike Schulz; Cristina Constantin; Kirsty S Vowinkel; Linus J Conrad; Aytug K Kiper; Wendy Gonzalez; Marianne Musinszki; Marie Tegtmeier; David C Pryde; Hassane Belabed; Marc Nazare; Bert L de Groot; Niels Decher; Bernd Fakler; Elisabeth P Carpenter; Stephen J Tucker; Thomas Baukrowitz
Journal:  Science       Date:  2019-02-22       Impact factor: 47.728

7.  Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent.

Authors:  Anna N Bukiya; Jacob E McMillan; Alexander L Fedinec; Shivaputra A Patil; Duane D Miller; Charles W Leffler; Abby L Parrill; Alex M Dopico
Journal:  Mol Pharmacol       Date:  2013-03-01       Impact factor: 4.436

Review 8.  Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology.

Authors:  Georgi V Petkov
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2014-07-02       Impact factor: 3.619

Review 9.  BK channel activators and their therapeutic perspectives.

Authors:  Bo H Bentzen; Søren-Peter Olesen; Lars C B Rønn; Morten Grunnet
Journal:  Front Physiol       Date:  2014-10-09       Impact factor: 4.566

10.  Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum.

Authors:  Christopher P Pratt; Dika A Kuljis; Gregg E Homanics; Jianjun He; Dmytro Kolodieznyi; Srikanth Dudem; Mark A Hollywood; Alison L Barth; Marcel P Bruchez
Journal:  Front Cell Neurosci       Date:  2017-10-31       Impact factor: 5.505
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