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Literature DB >> 22930447

Assessing the differential affinity of small molecules for noncanonical DNA structures.

Loic Stefan¹, Benoît Bertrand, Philippe Richard, Pierre Le Gendre, Franck Denat, Michel Picquet, David Monchaud.

Abstract

The targeting of higher-order DNA structures has been thoroughly developed with G-quadruplex DNA but not with other structures like branched DNA (also known as DNA junctions). Because these alternative higher-order DNA architectures might be of high biological relevance, we implemented a high-throughput version of the FRET melting assay that enabled us to map the interactions of a candidate with four different DNA structures (duplex- and quadruplex DNA, three- and four-way junctions) in a rapid and reliable manner. We also introduce a novel index, the BONDS (branched and other noncanonical DNA selectivity) index, to conveniently quantify this differential affinity.

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Year: 2012 PMID： 22930447 DOI： 10.1002/cbic.201200396

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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Cited

7 in total

Review 1. Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization.

Authors: Anton Simeonov
Journal: Expert Opin Drug Discov Date: 2013-06-06 Impact factor: 6.098

2. Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes.

Authors: Alessio Terenzi; Daniela Lötsch; Sushilla van Schoonhoven; Alexander Roller; Christian R Kowol; Walter Berger; Bernhard K Keppler; Giampaolo Barone
Journal: Dalton Trans Date: 2016-05-04 Impact factor: 4.390

3. Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

Authors: Benoît Bertrand; Julio Fernandez-Cestau; Jesus Angulo; Marco M D Cominetti; Zoë A E Waller; Mark Searcey; Maria A O'Connell; Manfred Bochmann
Journal: Inorg Chem Date: 2017-04-25 Impact factor: 5.165

Assessing the differential affinity of small molecules for noncanonical DNA structures.

Review 1. Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization.

2. Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes.

3. Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

4. TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro.

Review 5. DNA folds threaten genetic stability and can be leveraged for chemotherapy.

Review 6. Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment.

7. Small-Molecule-Based Self-Assembled Ligands for G-Quadruplex DNA Surface Recognition.

Assessing the differential affinity of small molecules for noncanonical DNA structures.

Review 1. Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization.

2. Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes.

3. Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

4. TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro.

Review 5. DNA folds threaten genetic stability and can be leveraged for chemotherapy.

Review 6. Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment.

7. Small-Molecule-Based Self-Assembled Ligands for G-Quadruplex DNA Surface Recognition.

3. Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.