Literature DB >> 2293032

A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis.

Y Mikami1, S F Yu, K Yazawa, K Fukushima, A Maeda, J Uno, K Terao, N Saito, A Kubo, K Suzuki.   

Abstract

During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LD50 value was 1.25 mg/kg and the ED50 value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68O12. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans.

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Year:  1990        PMID： 2293032     DOI： 10.1007/bf00436506

Source DB:  PubMed          Journal:  Mycopathologia        ISSN： 0301-486X            Impact factor:   2.574


  12 in total

1.  A lymphocytopenia producing factor from Nocardia.

Authors:  C M C JOHNSON; J DE VRIES; J W STEVENSON
Journal:  Can J Microbiol       Date:  1956-05       Impact factor: 2.419

2.  Biochemical studies of pigments from a pathogenic fungus; Microsporum cookei. VI. Formation of a xanthomegnin-bypass to the mitochondrial electron transport system.

Authors:  K Kawai; Y Nozawa
Journal:  Experientia       Date:  1979-06-15

3.  Antitumor activity of new semisynthetic saframycin derivatives.

Authors:  S Kaneda; C Hour-Young; K Yazawa; K Takahashi; Y Mikami; T Arai
Journal:  Jpn J Cancer Res       Date:  1986-10

4.  Identification of aerobic actinomycetes of clinical importance.

Authors:  M P Lechevalier
Journal:  J Lab Clin Med       Date:  1968-06

5.  Identification of producer and biological activities of new antibiotics, mimosamycin and chlorocarcins.

Authors:  Y Mikami; K Yokoyama; A Omi; T Arai
Journal:  J Antibiot (Tokyo)       Date:  1976-04       Impact factor: 2.649

6.  Free mycolic acids as criteria in the classification of Nocardia and the 'rhodochrous' complex.

Authors:  L Alashamaony; M Goodfellow; D E Minnikin
Journal:  J Gen Microbiol       Date:  1976-01

7.  Interaction of Nocardia asteroides at different phases of growth with in vitro-maintained macrophages obtained from the lungs of normal and immunized rabbits.

Authors:  B L Beaman
Journal:  Infect Immun       Date:  1979-10       Impact factor: 3.441

8.  Menaquinone composition of mycolic acid-containing actinomycetes and some sporoactinomycetes.

Authors:  M D Collins; M Goodfellow; D E Minnikin; G Alderson
Journal:  J Appl Bacteriol       Date:  1985-01

9.  Biosynthetic studies on saframycin A, a quinone antitumor antibiotic produced by Streptomyces lavendulae.

Authors:  Y Mikami; K Takahashi; K Yazawa; T Arai; M Namikoshi; S Iwasaki; S Okuda
Journal:  J Biol Chem       Date:  1985-01-10       Impact factor: 5.157

Review 10.  Nocardial infections in the immunocompromised host: A detailed study in a defined population.

Authors:  G L Simpson; E B Stinson; M J Egger; J S Remington
Journal:  Rev Infect Dis       Date:  1981 May-Jun
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  5 in total

1.  Microbial gutta-percha degradation shares common steps with rubber degradation by Nocardia nova SH22a.

Authors:  Quan Luo; Sebastian Hiessl; Anja Poehlein; Alexander Steinbüchel
Journal:  Appl Environ Microbiol       Date:  2012-12-07       Impact factor: 4.792

2.  Nocardia asteroides culture filtrates cause dopamine depletion and cytotoxicity in PC12 cells.

Authors:  Dianne M Camp; David A Loeffler; Bnan A Razoky; Stanley Tam; Blaine L Beaman; Peter A LeWitt
Journal:  Neurochem Res       Date:  2003-09       Impact factor: 3.996

Review 3.  Nocardia species: host-parasite relationships.

Authors:  B L Beaman; L Beaman
Journal:  Clin Microbiol Rev       Date:  1994-04       Impact factor: 26.132

4.  Light and electron microscopic studies on experimental nocardia-toxicosis in mice.

Authors:  K Terao; E Ito; M Oarada; M Ohkusu; K Yazawa; Y Mikami; K Igarashi
Journal:  Mycopathologia       Date:  1992-08       Impact factor: 2.574

Review 5.  Pathogenic Nocardia: A diverse genus of emerging pathogens or just poorly recognized?

Authors:  Heer H Mehta; Yousif Shamoo
Journal:  PLoS Pathog       Date:  2020-03-05       Impact factor: 6.823
  5 in total

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