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Literature DB >> 22929101

Airway smooth muscle in asthma: just a target for bronchodilation?

Judith L Black¹, Reynold A Panettieri, Audreesh Banerjee, Patrick Berger.

Abstract

Airway smooth muscle (ASM) has long been recognized as the main cell type responsible for bronchial hyperresponsiveness. It has, thus, been considered as a target for bronchodilation. In asthma, however, there is a complex relationship between ASM and inflammatory cells, such as mast cells and T lymphocytes. Moreover, the increased ASM mass in asthmatic airways is one of the key features of airway remodeling. This article aims to review the main concepts about the 3 possible roles of ASM in asthma: (1) contractile tone, (2) inflammatory response, and (3) remodeling.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2012 PMID： 22929101 PMCID： PMC3431506 DOI： 10.1016/j.ccm.2012.05.002

Source DB: PubMed Journal: Clin Chest Med ISSN： 0272-5231 Impact factor: 2.878

174 in total

1. Inflammation of bronchial smooth muscle in allergic asthma.

Authors: H Begueret; P Berger; J M Vernejoux; L Dubuisson; R Marthan; J M Tunon-de-Lara
Journal: Thorax Date: 2007-01 Impact factor: 9.139

2. Isoprostane-induced airway hyperresponsiveness is dependent on internal Ca2+ handling and Rho/ROCK signaling.

Authors: Caiqiong Liu; Tracy Tazzeo; Luke J Janssen
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2006-06-30 Impact factor: 5.464

3. Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.

Authors: Satoru Ito; Hiroaki Kume; Tetsuya Oguma; Yasushi Ito; Masashi Kondo; Kaoru Shimokata; Béla Suki; Keiji Naruse
Journal: Eur J Pharmacol Date: 2006-09-08 Impact factor: 4.432

4. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.

Authors: Naoya Takeda; Masashi Kondo; Satoru Ito; Yasushi Ito; Kaoru Shimokata; Hiroaki Kume
Journal: Am J Respir Cell Mol Biol Date: 2006-07-20 Impact factor: 6.914

5. Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma.

Authors: Davinder Kaur; Ruth Saunders; Patrick Berger; Salman Siddiqui; Lucy Woodman; Andrew Wardlaw; Peter Bradding; Christopher E Brightling
Journal: Am J Respir Crit Care Med Date: 2006-09-07 Impact factor: 21.405

6. Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation.

Authors: Hiroaki Kume; Naoya Takeda; Tetsuya Oguma; Satoru Ito; Masashi Kondo; Yasushi Ito; Kaoru Shimokata
Journal: J Pharmacol Exp Ther Date: 2006-11-14 Impact factor: 4.030

7. IL-13Ralpha2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca+ signaling.

Authors: Julia Kellner; Fernando Gamarra; Ulrich Welsch; Rudolf A Jörres; Rudolf M Huber; Albrecht Bergner
Journal: Int Arch Allergy Immunol Date: 2006-11-13 Impact factor: 2.749

8. Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal proasthmatic changes in airway function.

Authors: Haviva Veler; Aihua Hu; Sumbul Fatma; Judith S Grunstein; Christine M DeStephan; Donald Campbell; Jordan S Orange; Michael M Grunstein
Journal: J Immunol Date: 2007-03-15 Impact factor: 5.422

9. Asthma treatment and asthma prevention: a tale of 2 parallel pathways.

Authors: Fernando D Martinez
Journal: J Allergy Clin Immunol Date: 2006-11-27 Impact factor: 10.793

Review 10. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.

Authors: S S An; T R Bai; J H T Bates; J L Black; R H Brown; V Brusasco; P Chitano; L Deng; M Dowell; D H Eidelman; B Fabry; N J Fairbank; L E Ford; J J Fredberg; W T Gerthoffer; S H Gilbert; R Gosens; S J Gunst; A J Halayko; R H Ingram; C G Irvin; A L James; L J Janssen; G G King; D A Knight; A M Lauzon; O J Lakser; M S Ludwig; K R Lutchen; G N Maksym; J G Martin; T Mauad; B E McParland; S M Mijailovich; H W Mitchell; R W Mitchell; W Mitzner; T M Murphy; P D Paré; R Pellegrino; M J Sanderson; R R Schellenberg; C Y Seow; P S P Silveira; P G Smith; J Solway; N L Stephens; P J Sterk; A G Stewart; D D Tang; R S Tepper; T Tran; L Wang
Journal: Eur Respir J Date: 2007-05 Impact factor: 16.671

26 in total

1. IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle.

Authors: Mac B Robinson; Deepak A Deshpande; Jeffery Chou; Wei Cui; Shelly Smith; Carl Langefeld; Annette T Hastie; Eugene R Bleecker; Gregory A Hawkins
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2015-05-22 Impact factor: 5.464

Review 2. Phosphoinositide 3-Kinase in Asthma: Novel Roles and Therapeutic Approaches.

Authors: Edwin J Yoo; Christie A Ojiaku; Krishna Sunder; Reynold A Panettieri
Journal: Am J Respir Cell Mol Biol Date: 2017-06 Impact factor: 6.914

3. Gα₁₂ facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner.

Authors: Edwin J Yoo; Gaoyuan Cao; Cynthia J Koziol-White; Christie A Ojiaku; Krishna Sunder; Joseph A Jude; James V Michael; Hong Lam; Ivan Pushkarsky; Robert Damoiseaux; Dino Di Carlo; Kwangmi Ahn; Steven S An; Raymond B Penn; Reynold A Panettieri
Journal: Br J Pharmacol Date: 2017-11-12 Impact factor: 8.739

4. The effectiveness of fish oil supplementation in asthmatic rats is limited by an inefficient action on ASM function.

Authors: D T S Z Miranda; A L Zanatta; B C L Dias; R T H Fogaça; J B B Maurer; L Donatti; P C Calder; A Nishiyama
Journal: Lipids Date: 2013-06-07 Impact factor: 1.880

5. Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy.

Authors: Sarah K Sasse; Vineela Kadiyala; Thomas Danhorn; Reynold A Panettieri; Tzu L Phang; Anthony N Gerber
Journal: Am J Respir Cell Mol Biol Date: 2017-08 Impact factor: 6.914

Review 6. Interaction between endoplasmic/sarcoplasmic reticulum stress (ER/SR stress), mitochondrial signaling and Ca(2+) regulation in airway smooth muscle (ASM).

Authors: Philippe Delmotte; Gary C Sieck
Journal: Can J Physiol Pharmacol Date: 2014-11-25 Impact factor: 2.273