Literature DB >> 22929095

Biomarkers in asthma: a real hope to better manage asthma.

Serpil C Erzurum1, Benjamin M Gaston.   

Abstract

Diagnosis and treatment of asthma are currently based on assessment of patient symptoms and physiologic tests of airway reactivity. Research over the past decade has identified an array of biochemical and cellular biomarkers, which reflect the heterogeneous and multiple mechanistic pathways that may lead to asthma. These mechanistic biomarkers offer hope for optimal design of therapies targeting the specific pathways that lead to inflammation. This article provides an overview of blood, urine, and airway biomarkers; summarizes the pathologic pathways that they signify; and begins to describe the utility of biomarkers in the future care of patients with asthma.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22929095      PMCID： PMC3494969          DOI： 10.1016/j.ccm.2012.06.007

Source DB:  PubMed          Journal:  Clin Chest Med        ISSN： 0272-5231            Impact factor:   2.878


  138 in total

1.  Do NHLBI lung function criteria apply to children? A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999-2002.

Authors:  Keith Paull; Ronina Covar; Neal Jain; Erwin W Gelfand; Joseph D Spahn
Journal:  Pediatr Pulmonol       Date:  2005-04

2.  Lebrikizumab treatment in adults with asthma.

Authors:  Jonathan Corren; Robert F Lemanske; Nicola A Hanania; Phillip E Korenblat; Merdad V Parsey; Joseph R Arron; Jeffrey M Harris; Heleen Scheerens; Lawren C Wu; Zheng Su; Sofia Mosesova; Mark D Eisner; Sean P Bohen; John G Matthews
Journal:  N Engl J Med       Date:  2011-08-03       Impact factor: 91.245

Review 3.  The biochemistry of asthma.

Authors:  Benjamin Gaston
Journal:  Biochim Biophys Acta       Date:  2011-06-22

4.  Exhaled nitric oxide in a population-based study of asthma and allergy in schoolchildren.

Authors:  S L Nordvall; C Janson; P Kalm-Stephens; T Foucard; K Torén; K Alving
Journal:  Allergy       Date:  2005-04       Impact factor: 13.146

5.  Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD.

Authors:  Midori Hashimoto; Hiroshi Tanaka; Shosaku Abe
Journal:  Chest       Date:  2005-03       Impact factor: 9.410

6.  Obesity and asthma: an association modified by age of asthma onset.

Authors:  Fernando Holguin; Eugene R Bleecker; William W Busse; William J Calhoun; Mario Castro; Serpil C Erzurum; Anne M Fitzpatrick; Benjamin Gaston; Elliot Israel; Nizar N Jarjour; Wendy C Moore; Stephen P Peters; Michael Yonas; W Gerald Teague; Sally E Wenzel
Journal:  J Allergy Clin Immunol       Date:  2011-06       Impact factor: 10.793

7.  Use of exhaled nitric oxide measurements to guide treatment in chronic asthma.

Authors:  Andrew D Smith; Jan O Cowan; Karen P Brassett; G Peter Herbison; D Robin Taylor
Journal:  N Engl J Med       Date:  2005-05-24       Impact factor: 91.245

8.  Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children.

Authors:  Samuel H Wedes; Weijia Wu; Suzy A A Comhair; Karen M McDowell; Joseph A DiDonato; Serpil C Erzurum; Stanley L Hazen
Journal:  J Pediatr       Date:  2011-03-10       Impact factor: 4.406

9.  Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity.

Authors:  Suzy A A Comhair; Weiling Xu; Sudakshina Ghosh; Frederik B J M Thunnissen; Alexandru Almasan; William J Calhoun; Allison J Janocha; Lemin Zheng; Stanley L Hazen; Serpil C Erzurum
Journal:  Am J Pathol       Date:  2005-03       Impact factor: 4.307

Review 10.  Use of induced sputum to examine airway inflammation in childhood asthma.

Authors:  P G Gibson
Journal:  J Allergy Clin Immunol       Date:  1998-11       Impact factor: 10.793
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  4 in total

1.  Metabolomic Endotype of Asthma.

Authors:  Suzy A A Comhair; Jonathan McDunn; Carole Bennett; Jade Fettig; Serpil C Erzurum; Satish C Kalhan
Journal:  J Immunol       Date:  2015-06-05       Impact factor: 5.422

Review 2.  The emerging roles of eosinophils: Implications for the targeted treatment of eosinophilic-associated inflammatory conditions.

Authors:  Carlo Lombardi; Alvise Berti; Marcello Cottini
Journal:  Curr Res Immunol       Date:  2022-03-21

3.  The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma.

Authors:  Chia-Rui Shen; Horng-Heng Juang; Hui-Shan Chen; Ching-Jen Yang; Chia-Jen Wu; Meng-Hua Lee; Yih-Shiou Hwang; Ming-Ling Kuo; Ya-Shan Chen; Jeen-Kuan Chen; Chao-Lin Liu
Journal:  Int J Mol Sci       Date:  2015-11-16       Impact factor: 5.923

4.  Protein and microRNA biomarkers from lavage, urine, and serum in military personnel evaluated for dyspnea.

Authors:  Joseph N Brown; Heather M Brewer; Carrie D Nicora; Karl K Weitz; Michael J Morris; Andrew J Skabelund; Joshua N Adkins; Richard D Smith; Ji-Hoon Cho; Richard Gelinas
Journal:  BMC Med Genomics       Date:  2014-10-05       Impact factor: 3.063
  4 in total

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