Literature DB >> 22928836

Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells.

Hyuk-Hwan Song1, Hee-Sung Chae, Sei-Ryang Oh, Hyeong-Kyu Lee, Young-Won Chin.   

Abstract

In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D(2) and leukotriene C(4) in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D(2), leukotriene C(4), and the phosphorylation of Akt.

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Year:  2012        PMID： 22928836     DOI： 10.1142/S0192415X12500796

Source DB:  PubMed          Journal:  Am J Chin Med        ISSN： 0192-415X            Impact factor:   4.667


  7 in total

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Journal:  Mediators Inflamm       Date:  2014-11-23       Impact factor: 4.711

Review 3.  Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era.

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Review 4.  The Medicinal Values of Culinary-Medicinal Royal Sun Mushroom (Agaricus blazei Murrill).

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Journal:  Evid Based Complement Alternat Med       Date:  2013-10-31       Impact factor: 2.629

5.  Effects of Dietary Supplementation with Agaricus sylvaticus Schaeffer on Glycemia and Cholesterol after Streptozotocin-Induced Diabetes in Rats.

Authors:  Marcelo Betti Mascaro; Cristiane Miranda França; Kamilla F Esquerdo; Marx A N Lara; Nilsa S Y Wadt; Erna E Bach
Journal:  Evid Based Complement Alternat Med       Date:  2014-05-26       Impact factor: 2.629

6.  Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial.

Authors:  Faiza Mahmood; Geir Hetland; Ivo Nentwich; Mohammad Reza Mirlashari; Reza Ghiasvand; Lise Sofie Haug Nissen-Meyer
Journal:  Nutrients       Date:  2019-10-02       Impact factor: 5.717

Review 7.  Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation?

Authors:  Geir Hetland; Egil Johnson; Soosaipillai V Bernardshaw; Bjørn Grinde
Journal:  Scand J Immunol       Date:  2020-07-29       Impact factor: 3.889
  7 in total

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