BACKGROUND: Higher mortality for patients with aneurysmal subarachnoid haemorrhage has been reported. AIMS: In families with intracranial aneurysms, we sought to determine whether mortality among subjects with intracranial aneurysm (affected) was higher and related to rupture, compared with unaffected family members. METHODS: Subjects enrolled in the Familial Intracranial Aneurysm protocol were contacted yearly and their status was obtained. If reported to be deceased, the cause of death was verified by available records. A Cox proportional hazards model was utilized to compare mortality rates. RESULTS: Of the 2794 subjects, 1073 were affected and 1721 were unaffected. There were 8525 person-years of follow-up (mean 3·05 ± 1·73 years) and 85 deaths. Age at study entry for the affected (58·4 ± 11·9 years) was significantly older (P < 0·0001) than for the unaffected (52·2 ± 16·1). After adjusting for age, the overall mortality rate for the affected subjects was not significantly different from that for the unaffected (Rate Ratio [RR] 1·26, 95% confidence interval 0·82-1·93, P = 0·292). There was a strong effect modification due to age. The mortality rate ratio of the affected to the unaffected who were ≤60 years of age was RR = 3·48 (95% confidence interval: 1·59-7·63, P = 0·002), the rate for the affected subjects who were ≥60 was less than the rate for the unaffected (RR = 0·69, 95% confidence interval: 0·404-1·19, P = 0·178). The affected who had ruptures had 2·62 times the mortality rate as those without ruptures (95% confidence interval 1·43-4·80, P = 0·002). CONCLUSION: The overall mortality was similar for the affected and unaffected subjects in this cohort. Among the affected only, those with ruptured intracranial aneurysm had a higher mortality rate than those without ruptured.
BACKGROUND: Higher mortality for patients with aneurysmal subarachnoid haemorrhage has been reported. AIMS: In families with intracranial aneurysms, we sought to determine whether mortality among subjects with intracranial aneurysm (affected) was higher and related to rupture, compared with unaffected family members. METHODS: Subjects enrolled in the Familial Intracranial Aneurysm protocol were contacted yearly and their status was obtained. If reported to be deceased, the cause of death was verified by available records. A Cox proportional hazards model was utilized to compare mortality rates. RESULTS: Of the 2794 subjects, 1073 were affected and 1721 were unaffected. There were 8525 person-years of follow-up (mean 3·05 ± 1·73 years) and 85 deaths. Age at study entry for the affected (58·4 ± 11·9 years) was significantly older (P < 0·0001) than for the unaffected (52·2 ± 16·1). After adjusting for age, the overall mortality rate for the affected subjects was not significantly different from that for the unaffected (Rate Ratio [RR] 1·26, 95% confidence interval 0·82-1·93, P = 0·292). There was a strong effect modification due to age. The mortality rate ratio of the affected to the unaffected who were ≤60 years of age was RR = 3·48 (95% confidence interval: 1·59-7·63, P = 0·002), the rate for the affected subjects who were ≥60 was less than the rate for the unaffected (RR = 0·69, 95% confidence interval: 0·404-1·19, P = 0·178). The affected who had ruptures had 2·62 times the mortality rate as those without ruptures (95% confidence interval 1·43-4·80, P = 0·002). CONCLUSION: The overall mortality was similar for the affected and unaffected subjects in this cohort. Among the affected only, those with ruptured intracranial aneurysm had a higher mortality rate than those without ruptured.
Authors: Brett M Kissela; Laura Sauerbeck; Daniel Woo; Jane Khoury; Janice Carrozzella; Arthur Pancioli; Edward Jauch; Charles J Moomaw; Rakesh Shukla; James Gebel; Robert Fontaine; Joseph Broderick Journal: Stroke Date: 2002-05 Impact factor: 7.914
Authors: M S Sandvei; E B Mathiesen; L J Vatten; T B Müller; H Lindekleiv; T Ingebrigtsen; I Njølstad; T Wilsgaard; M-L Løchen; A Vik; P R Romundstad Journal: Neurology Date: 2011-11-02 Impact factor: 9.910
Authors: Ranjan Deka; Daniel L Koller; Dongbing Lai; Subba Rao Indugula; Guangyun Sun; Daniel Woo; Laura Sauerbeck; Charles J Moomaw; Richard Hornung; E Sander Connolly; Craig Anderson; Guy Rouleau; Irene Meissner; Joan E Bailey-Wilson; John Huston; Robert D Brown; Dawn O Kleindorfer; Matthew L Flaherty; Carl D Langefeld; Tatiana Foroud; Joseph P Broderick Journal: Stroke Date: 2010-02-26 Impact factor: 7.914
Authors: Robert D Brown; John Huston; Richard Hornung; Tatiana Foroud; David F Kallmes; Dawn Kleindorfer; Irene Meissner; Daniel Woo; Laura Sauerbeck; Joseph Broderick Journal: J Neurosurg Date: 2008-06 Impact factor: 5.115
Authors: Tatiana Foroud; Laura Sauerbeck; Robert Brown; Craig Anderson; Daniel Woo; Dawn Kleindorfer; Matthew L Flaherty; Ranjan Deka; Richard Hornung; Irene Meissner; Joan E Bailey-Wilson; Carl Langefeld; Guy Rouleau; E Sander Connolly; Dongbing Lai; Daniel L Koller; John Huston; Joseph P Broderick Journal: BMC Med Genet Date: 2009-01-13 Impact factor: 2.103