Literature DB >> 22926833

Actinomycetes genome engineering approaches.

Theresa Siegl1, Andriy Luzhetskyy.   

Abstract

This review provides an overview of new technologies for DNA manipulations in actinomycetes exploiting recombinogenic engineering (Flp-FRT, Cre-loxP, Dre-rox, Tn5, GusA and I-SceI systems). We will describe some new vectors recently developed for engineering of complex phenotypes in actinomycetes. Several site-specific recombinases, transposons, reporter genes and I-SceI endonuclease have been utilized for genome manipulation in actinomycetes. Novel molecular tools will help to overcome many technical difficulties and will encourage new efforts to address the function of actinomycete genes.

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Year:  2012        PMID： 22926833     DOI： 10.1007/s10482-012-9795-y

Source DB:  PubMed          Journal:  Antonie Van Leeuwenhoek        ISSN： 0003-6072            Impact factor:   2.271


  10 in total

1.  Modular and Integrative Vectors for Synthetic Biology Applications in Streptomyces spp.

Authors:  Céline Aubry; Jean-Luc Pernodet; Sylvie Lautru
Journal:  Appl Environ Microbiol       Date:  2019-08-01       Impact factor: 4.792

2.  Testing the utility of site-specific recombinases for manipulations of genome of moenomycin producer Streptomyces ghanaensis ATCC14672.

Authors:  M Lopatniuk; B Ostash; R Makitrynskyy; S Walker; A Luzhetskyy; V Fedorenko
Journal:  J Appl Genet       Date:  2015-03-24       Impact factor: 3.240

3.  Development of an Improved System for the Generation of Knockout Mutants of Amycolatopsis sp. Strain ATCC 39116.

Authors:  Florian Meyer; Hilke Pupkes; Alexander Steinbüchel
Journal:  Appl Environ Microbiol       Date:  2017-01-17       Impact factor: 4.792

4.  Metabolic Engineering of the Actinomycete Amycolatopsis sp. Strain ATCC 39116 towards Enhanced Production of Natural Vanillin.

Authors:  Christian Fleige; Florian Meyer; Alexander Steinbüchel
Journal:  Appl Environ Microbiol       Date:  2016-05-16       Impact factor: 4.792

Review 5.  Direct Capture Technologies for Genomics-Guided Discovery of Natural Products.

Authors:  Andrew N Chan; Kevin C Santa Maria; Bo Li
Journal:  Curr Top Med Chem       Date:  2016       Impact factor: 3.295

Review 6.  Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds.

Authors:  Dipesh Dhakal; Anaya Raj Pokhrel; Biplav Shrestha; Jae Kyung Sohng
Journal:  Front Microbiol       Date:  2017-06-15       Impact factor: 5.640

7.  Chromosomal position effect influences the heterologous expression of genes and biosynthetic gene clusters in Streptomyces albus J1074.

Authors:  Bohdan Bilyk; Liliya Horbal; Andriy Luzhetskyy
Journal:  Microb Cell Fact       Date:  2017-01-04       Impact factor: 5.328

8.  Marker-Free Genome Engineering in Amycolatopsis Using the pSAM2 Site-Specific Recombination System.

Authors:  Luísa D F Santos; Laëtitia Caraty-Philippe; Emmanuelle Darbon; Jean-Luc Pernodet
Journal:  Microorganisms       Date:  2022-04-16

Review 9.  Chassis optimization as a cornerstone for the application of synthetic biology based strategies in microbial secondary metabolism.

Authors:  Tiago Beites; Marta V Mendes
Journal:  Front Microbiol       Date:  2015-09-09       Impact factor: 5.640

10.  Insights into naturally minimised Streptomyces albus J1074 genome.

Authors:  Nestor Zaburannyi; Mariia Rabyk; Bohdan Ostash; Victor Fedorenko; Andriy Luzhetskyy
Journal:  BMC Genomics       Date:  2014-02-05       Impact factor: 3.969
  10 in total

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