| Literature DB >> 22925018 |
Narendran Pradeep Kumar1, Shanmugavelu Sabesan, Kaliannagounder Krishnamoorthy, Purushothaman Jambulingam.
Abstract
We detected Chikungunya virus (CHIKV) infection among wild populations of Aedes albopictus female specimens during the CHIKV outbreaks of 2009 and 2006 collected in different localities in Kerala State, India. The envelope 1 gene (E1) sequences of the virus isolate 2009 from the mosquito species showed close genetic relatedness (Kimura 2 Parameter genetic distance=0.0013) to CHIKV-positive isolates from human serum samples from the same area. E1 gene sequences from Ae. albopictus, as well as from human isolates, had the crucial non-synonymous C/T mutation at position 10670, leading to the A226V amino acid change. This natural inclination indicated the role of this mosquito species in the transmission of CHIKV during its recent outbreaks in Kerala State.Entities:
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Year: 2012 PMID： 22925018 DOI： 10.1089/vbz.2012.0969
Source DB: PubMed Journal: Vector Borne Zoonotic Dis ISSN： 1530-3667 Impact factor: 2.133