| Literature DB >> 22924811 |
Chung-Min Park1, Wei Niu, Chunrong Liu, Tyler D Biggs, Jiantao Guo, Ming Xian.
Abstract
A proline-based phosphine template enabling a rapid Staudinger ligation of azide-containing substrates under mild conditions is reported. This reaction has a second-order rate constant of 1.12 M(-1) s(-1). It is expected that the proline-based Staudinger ligation strategy will be a useful method for bioconjugation and proline based peptide coupling.Entities:
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Year: 2012 PMID： 22924811 DOI： 10.1021/ol3022484
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005