Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Structure-activity relationship of a broad-spectrum insect odorant receptor agonist.

Literature DB >> 22924767

Structure-activity relationship of a broad-spectrum insect odorant receptor agonist.

Robert W Taylor¹, Ian M Romaine, Chao Liu, Poornima Murthi, Patrick L Jones, Alex G Waterson, Gary A Sulikowski, Laurence J Zwiebel.

Abstract

Agonism of insect odorant receptor (OR) cation channels may represent a new strategy for the manipulation of destructive insect olfactory-driven behaviors. We have explored the chemical space around VUAA1, the first in class agonist of the obligate OR co-receptor ion channel (Orco), and describe novel compound analogues with increased potency across insect taxa. Functional analyses reveal several of these VUAA1 structural analogues display significantly greater potency as compared to the activity of the previously described active compounds in mobility-based behavioral assays on mosquito larvae.

Mesh：

Substances：

Year: 2012 PMID： 22924767 DOI： 10.1021/cb300331z

Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100

Keyword Cloud
Cited

21 in total

1. Inner Workings: How do mosquitoes smell us? The answers could help eradicate disease.

Authors: Helen H Shen
Journal: Proc Natl Acad Sci U S A Date: 2017-02-28 Impact factor: 11.205

2. Peripheral olfactory signaling in insects.

Authors: Eunho Suh; Jonathan Bohbot; Laurence J Zwiebel
Journal: Curr Opin Insect Sci Date: 2014-12-01 Impact factor: 5.186

3. Phenylthiophenecarboxamide antagonists of the olfactory receptor co-receptor subunit from a mosquito.

Authors: Sisi Chen; Charles W Luetje
Journal: PLoS One Date: 2013-12-17 Impact factor: 3.240

4. Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from Drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation.

Authors: Rebecca M Turner; Stephen L Derryberry; Brijesh N Kumar; Thomas Brittain; Laurence J Zwiebel; Richard D Newcomb; David L Christie
Journal: J Biol Chem Date: 2014-09-30 Impact factor: 5.157

10. In situ tip-recordings found no evidence for an Orco-based ionotropic mechanism of pheromone-transduction in Manduca sexta.

Authors: Andreas Nolte; Nico W Funk; Latha Mukunda; Petra Gawalek; Achim Werckenthin; Bill S Hansson; Dieter Wicher; Monika Stengl
Journal: PLoS One Date: 2013-05-03 Impact factor: 3.240

Structure-activity relationship of a broad-spectrum insect odorant receptor agonist.

1. Inner Workings: How do mosquitoes smell us? The answers could help eradicate disease.

2. Peripheral olfactory signaling in insects.

3. Phenylthiophenecarboxamide antagonists of the olfactory receptor co-receptor subunit from a mosquito.

4. Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from Drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation.

Review 5. The role of the coreceptor Orco in insect olfactory transduction.

6. Narrow SAR in odorant sensing Orco receptor agonists.

7. Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit.

8. Odorant receptor-mediated sperm activation in disease vector mosquitoes.

9. Role of the Vector in Arbovirus Transmission.

10. In situ tip-recordings found no evidence for an Orco-based ionotropic mechanism of pheromone-transduction in Manduca sexta.