Literature DB >> 22924688

PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.

Timothy D Cushing1, Daniela P Metz, Douglas A Whittington, Lawrence R McGee.   

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Year:  2012        PMID： 22924688     DOI： 10.1021/jm300847w

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  19 in total

1.  Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles.

Authors:  Brian S Safina; Richard L Elliott; Andrew K Forrest; Robert A Heald; Jeremy M Murray; Jim Nonomiya; Jodie Pang; Laurent Salphati; Eileen M Seward; Steven T Staben; Mark Ultsch; Binqing Wei; Wenqian Yang; Daniel P Sutherlin
Journal:  ACS Med Chem Lett       Date:  2017-08-25       Impact factor: 4.345

2.  Concise SAR Exploration Based on the "Head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds.

Authors:  Satoru Noji; Noriyoshi Seki; Takaki Maeba; Takayuki Sakai; Eiichi Watanabe; Katsuya Maeda; Kyoko Fukushima; Toru Noguchi; Kazuya Ogawa; Yukiyo Toyonaga; Tamotsu Negoro; Hisashi Kawasaki; Makoto Shiozaki
Journal:  ACS Med Chem Lett       Date:  2016-08-03       Impact factor: 4.345

3.  Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury.

Authors:  Lei Huang; Prativa Sherchan; Yuechun Wang; Cesar Reis; Richard L Applegate; Jiping Tang; John H Zhang
Journal:  J Neurosci       Date:  2015-07-22       Impact factor: 6.167

4.  Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.

Authors:  Catherine A Evans; Tao Liu; André Lescarbeau; Somarajan J Nair; Louis Grenier; Johan A Pradeilles; Quentin Glenadel; Thomas Tibbitts; Ann M Rowley; Jonathan P DiNitto; Erin E Brophy; Erin L O'Hearn; Janid A Ali; David G Winkler; Stanley I Goldstein; Patrick O'Hearn; Christian M Martin; Jennifer G Hoyt; John R Soglia; Culver Cheung; Melissa M Pink; Jennifer L Proctor; Vito J Palombella; Martin R Tremblay; Alfredo C Castro
Journal:  ACS Med Chem Lett       Date:  2016-07-22       Impact factor: 4.345

5.  Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion.

Authors:  Shilong Zheng; Qiu Zhong; Quan Jiang; Madhusoodanan Mottamal; Qiang Zhang; Naijue Zhu; Matthew E Burow; Rebecca A Worthylake; Guangdi Wang
Journal:  ACS Med Chem Lett       Date:  2013-01-15       Impact factor: 4.345

6.  Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.

Authors:  Maria Galluzzo; Elisa Ciraolo; Monica Lucattelli; Eriola Hoxha; Martina Ulrich; Carlo Cosimo Campa; Giuseppe Lungarella; Gerd Doring; Zhe Zhou-Suckow; Marcus Mall; Emilio Hirsch; Virginia De Rose
Journal:  Mediators Inflamm       Date:  2015-06-21       Impact factor: 4.711

7.  The Concise Guide to PHARMACOLOGY 2013/14: enzymes.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

8.  The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies.

Authors:  Kerrie Faia; Kerry White; Erin Murphy; Jennifer Proctor; Melissa Pink; Nicole Kosmider; Karen McGovern; Jeffery Kutok
Journal:  PLoS One       Date:  2018-08-01       Impact factor: 3.240

9.  Duvelisib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Phosphoinositide 3-Kinases.

Authors:  Daniel A Rodrigues; Fernanda S Sagrillo; Carlos A M Fraga
Journal:  Pharmaceuticals (Basel)       Date:  2019-05-06

10.  NF-κB inhibition alleviates carbon tetrachloride-induced liver fibrosis via suppression of activated hepatic stellate cells.

Authors:  Fei Wang; Shuyuan Liu; Taiping DU; Hao Chen; Zhiyong Li; Jingwang Yan
Journal:  Exp Ther Med       Date:  2014-04-14       Impact factor: 2.447
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