Young Ho Lee1, Gwan Gyu Song. 1. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Korea University Medical Center, Seoul, Korea. lyhcgh@korea.ac.kr
Abstract
OBJECTIVE: The aim of this study was to determine whether the tumor necrosis factor-alpha-inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. METHODS: The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and SLE susceptibility, using fixed and random effects models. RESULTS: A total of eight comparative studies were included in this meta-analysis, which included four Asian, three European, and one African American population. Meta-analysis revealed that an association was found between the minor allele of rs2230926 and SLE in all subjects (odds ratio [OR] 1.848, 95% confidence interval [CI] 1.547-2.208, p<1.0×10(-9)). After stratification by ethnicity, the minor allele of rs2230926 was found to be significantly associated with SLE in Asians and Europeans (OR 1.821, 95% CI 1.495-2.219, p<1.0×10(-9); OR 2.251, 95% CI 1.830-2.768, p<1.0×10(-9)). In addition, a significant association was found between the minor allele of the rs5029939 polymorphism and the risk of developing SLE in all study subjects and Europeans (OR 1.804, 95% CI 1.255-2.592, p=0.001; OR 2.145, 95% CI 1.731-2.658, p<1.0×10(-9)). Furthermore, an association was found between the minor allele of rs3757173 and SLE in all study subjects (OR 1.540, 95% CI 1.017-2.331, p=0.041). However, no association was found between SLE susceptibility and rs6922466 (OR 0.953, 95% CI 0.812-1.120, p=0.561). CONCLUSIONS: This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with SLE susceptibility in different ethnic groups, namely in Asians and Europeans.
OBJECTIVE: The aim of this study was to determine whether the tumor necrosis factor-alpha-inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. METHODS: The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and SLE susceptibility, using fixed and random effects models. RESULTS: A total of eight comparative studies were included in this meta-analysis, which included four Asian, three European, and one African American population. Meta-analysis revealed that an association was found between the minor allele of rs2230926 and SLE in all subjects (odds ratio [OR] 1.848, 95% confidence interval [CI] 1.547-2.208, p<1.0×10(-9)). After stratification by ethnicity, the minor allele of rs2230926 was found to be significantly associated with SLE in Asians and Europeans (OR 1.821, 95% CI 1.495-2.219, p<1.0×10(-9); OR 2.251, 95% CI 1.830-2.768, p<1.0×10(-9)). In addition, a significant association was found between the minor allele of the rs5029939 polymorphism and the risk of developing SLE in all study subjects and Europeans (OR 1.804, 95% CI 1.255-2.592, p=0.001; OR 2.145, 95% CI 1.731-2.658, p<1.0×10(-9)). Furthermore, an association was found between the minor allele of rs3757173 and SLE in all study subjects (OR 1.540, 95% CI 1.017-2.331, p=0.041). However, no association was found between SLE susceptibility and rs6922466 (OR 0.953, 95% CI 0.812-1.120, p=0.561). CONCLUSIONS: This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with SLE susceptibility in different ethnic groups, namely in Asians and Europeans.
Authors: Zala Jevnikar; Rebecca Riise; Lina Odqvist; Lisa Öberg; Magdalena Rhedin; Dag Leonard; Linda Yrlid; Sonya Jackson; Johan Mattsson; Sambit Nanda; Philip Cohen; Axel Knebel; Simon Arthur; Kristofer Thörn; Elisabet Svenungsson; Andreas Jönsen; Iva Gunnarsson; Karolina Tandre; Andrei Alexsson; Alf Kastbom; Solbritt Rantapää-Dahlqvist; Maija-Leena Eloranta; Ann-Christine Syvänen; Anders Bengtsson; Patrik Johansson; Johanna K Sandling; Christopher Sjöwall; Lars Rönnblom; Barry Collins; Outi Vaarala Journal: Ann Rheum Dis Date: 2019-07-12 Impact factor: 19.103
Authors: George Couch; James E Redman; Lorenz Wernisch; Richard Newton; Shalini Malhotra; Sanford M Dawsey; Pierre Lao-Sirieix; Rebecca C Fitzgerald Journal: Cancer Prev Res (Phila) Date: 2016-04-12