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Literature DB >> 22924342

Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy.

Denis Drygin¹, Mustapha Haddach, Fabrice Pierre, David M Ryckman.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2012 PMID： 22924342 DOI： 10.1021/jm3009234

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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8 in total

1. Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket.

Authors: Hirofumi Nakano; Tsukasa Hasegawa; Hirotatsu Kojima; Takayoshi Okabe; Tetsuo Nagano
Journal: ACS Med Chem Lett Date: 2017-04-03 Impact factor: 4.345

2. Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate.

Authors: Leon Harrington; Stephen Cheley; Leila T Alexander; Stefan Knapp; Hagan Bayley
Journal: Proc Natl Acad Sci U S A Date: 2013-11-05 Impact factor: 11.205

3. Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

Authors: Victor J Cee; Frank Chavez; Bradley Herberich; Brian A Lanman; Liping H Pettus; Anthony B Reed; Bin Wu; Ryan P Wurz; Kristin L Andrews; Jie Chen; Dean Hickman; Jimmy Laszlo; Matthew R Lee; Nadia Guerrero; Bethany K Mattson; Yen Nguyen; Christopher Mohr; Karen Rex; Christine E Sastri; Paul Wang; Qiong Wu; Tian Wu; Yang Xu; Yihong Zhou; Jeffrey T Winston; J Russell Lipford; Andrew S Tasker; Hui-Ling Wang
Journal: ACS Med Chem Lett Date: 2016-02-12 Impact factor: 4.345

4. PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.

Authors: Esperanza Martín-Sánchez; Lina Odqvist; Socorro M Rodríguez-Pinilla; Margarita Sánchez-Beato; Giovanna Roncador; Beatriz Domínguez-González; Carmen Blanco-Aparicio; Ana M García Collazo; Esther González Cantalapiedra; Joaquín Pastor Fernández; Soraya Curiel del Olmo; Helena Pisonero; Rebeca Madureira; Carmen Almaraz; Manuela Mollejo; F Javier Alves; Javier Menárguez; Fernando González-Palacios; José Luis Rodríguez-Peralto; Pablo L Ortiz-Romero; Francisco X Real; Juan F García; James R Bischoff; Miguel A Piris
Journal: PLoS One Date: 2014-11-11 Impact factor: 3.240

Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy.

1. Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket.

2. Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate.

3. Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

4. PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.

5. Synthesis of new pyridothienopyrimidinone derivatives as Pim-1 inhibitors.

6. Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors.

7. Design, synthesis and biological evaluation of N-arylsulfonyl carbazoles as novel anticancer agents.

Review 8. The Role of PIM Kinases in Pediatric Solid Tumors.