Zelalem Asefa1, Awetash G/eyesus. 1. AAU-Medical Faculty, Department of Surgery, P. O. Box 16466, Addis Ababa-Ethiopia. agzelalem@yahoo.com
Abstract
BACKGROUND: Peptic ulcer perforation is a serious complication of peptic ulcer disease with a significant morbidity and mortality. OBJECTIVE: To evaluate 76 patients operated for peptic ulcer perforation and analyse the associated factors in Zewditu Memorial Hospital, Addis Ababa from September 2006 to August 2008. PATIENTS AND METHODS: A retrospective analysis of medical records of 76 patients who were operated up on for perforated peptic ulcer over a two year period (2006-2008). RESULTS: The male to female ratio was 6.6:1 with a mean age being 31.5 years. The most common presenting symptom was abdominal pain in 76 (100%) patients. History of smoking and khat chewing was documented in 53/64 (82.8%) and 48/64 (75%) of the patients respectively. Twenty five per cent of the patients gave no history of previous peptic ulcer disease. Seventy patients (92.1%) presented after 48 hours of their illness. The mean hospital stay was 14.5 days. Leucocytosis was found in 31.6% of the cases. Sixty five (85.5%) patients had duodenal ulcer perforation. Postoperative complications occurred in 24 (31.6%) patients. Twelve (15.8%) patients died in the hospital. CONCLUSION: Early presentation of patients and change in life style may reduce morbidity and mortality in patients with peptic ulcer perforation.
BACKGROUND: Peptic ulcer perforation is a serious complication of peptic ulcer disease with a significant morbidity and mortality. OBJECTIVE: To evaluate 76 patients operated for peptic ulcer perforation and analyse the associated factors in Zewditu Memorial Hospital, Addis Ababa from September 2006 to August 2008. PATIENTS AND METHODS: A retrospective analysis of medical records of 76 patients who were operated up on for perforated peptic ulcer over a two year period (2006-2008). RESULTS: The male to female ratio was 6.6:1 with a mean age being 31.5 years. The most common presenting symptom was abdominal pain in 76 (100%) patients. History of smoking and khat chewing was documented in 53/64 (82.8%) and 48/64 (75%) of the patients respectively. Twenty five per cent of the patients gave no history of previous peptic ulcer disease. Seventy patients (92.1%) presented after 48 hours of their illness. The mean hospital stay was 14.5 days. Leucocytosis was found in 31.6% of the cases. Sixty five (85.5%) patients had duodenal ulcer perforation. Postoperative complications occurred in 24 (31.6%) patients. Twelve (15.8%) patients died in the hospital. CONCLUSION: Early presentation of patients and change in life style may reduce morbidity and mortality in patients with peptic ulcer perforation.
Authors: Kjetil Søreide; Kenneth Thorsen; Ewen M Harrison; Juliane Bingener; Morten H Møller; Michael Ohene-Yeboah; Jon Arne Søreide Journal: Lancet Date: 2015-09-26 Impact factor: 79.321